Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation

Arnold L. Smith; David H. Smith; Damon R. Averill; Joseph Marino; E. Richard Moxon

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Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation

机译：腹膜内接种在婴儿大鼠中产生流感嗜血杆菌b脑膜炎

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Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.

机译：Sprague-Dawley大鼠对b型流感嗜血杆菌具有明显的年龄相关敏感性，与血清杀菌活性无关。经腹腔接种平均致死剂量细菌后存活至48小时的80％5天大的动物有组织学记录的脑膜炎。婴儿存活下来的动物成年后表现出脑功能障碍。该模型应有助于细菌性脑膜炎的实验研究。

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《Infection and immunity》 |1973年第2期|共13页
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Arnold L. Smith; David H. Smith; Damon R. Averill; Joseph Marino; E. Richard Moxon;
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中图分类医学免疫学;
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1. Adjunctive Treatment with Low-Dose Polymyxin B Improves Operant Response Rates and Latency in Infant Rats with Haemophilus influenzae Type b Meningitis [J] . Juan N Walterspiel, William F Vitulli Pediatric Research . 1989,第5期

机译：低剂量多粘菌素B的辅助治疗可改善b型流感嗜血杆菌脑膜炎婴儿大鼠的手术反应率和潜伏期。
2. Transposon insertion in a serine-specific minor tRNA coding sequence affects intraperitoneal survival of Haemophilus influenzae in the infant rat model [J] . Gerlach G, Anthony M, Deadman M, International journal of medical microbiology: IJMM . 2010,第4期

机译：转座子插入丝氨酸特异的次要tRNA编码序列会影响婴儿模型中流感嗜血杆菌的腹膜内存活
3. Intraperitoneal inoculation of Haemophilus influenzae local isolates in BALB/c mice model in the presence and absence of virulence enhancement agents [J] . N Mojgani, V Maldjae, M Rahbar, Indian Journal of Medical Microbiology . 2013,第2期

机译：在有和没有毒力增强剂的情况下，在BALB / c小鼠模型中腹膜内接种流感嗜血杆菌局部分离株
4. Investigations into treatment strategies aiding the immune response to Haemophilus Influenzae [C] . Rundell, A., DeCarlo, . 1997

机译：有助于对流感嗜血杆菌免疫应答的治疗策略的研究
5. Internalization and Trafficking of Nontypeable Haemophilus influenzae in Human Respiratory Epithelial Cells and the Roles of IgA1 Proteases for Optimal Internalization and Persistence. [D] . Clementi, Cara Franklin. 2013

机译：人类呼吸道上皮细胞中非典型流感嗜血杆菌的内在化和贩运以及IgA1蛋白酶对最佳内在化和持久性的作用。
6. Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation [O] . Arnold L. Smith, David H. Smith, Damon R. Averill Jr., 1973

机译：腹膜内接种在婴儿大鼠中产生流感嗜血杆菌b脑膜炎
7. Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation [O] . Arnold L. Smith, David H. Smith, Damon R. Averill, 1973

机译：腹膜内接种生产婴儿大鼠血液血液血液血管炎
8. Parenteral Aztreonam in the Treatment of Haemophilus influenzae Type B Meningitis in Egyptian Children. (Reannouncement with New Availability Information). [R] . Girgis, N. I., Abu El Ella, A. H., Farid, Z., 1988

机译：肠外阿兹特罗姆治疗埃及儿童B型流感嗜血杆菌炎。（重新公布新的可用性信息）。

Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation

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