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首页> 外文期刊>Infection and immunity >Distribution of cholera organisms in experimental Vibrio cholerae infections: proposed mechanisms of pathogenesis and antibacterial immunity.
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Distribution of cholera organisms in experimental Vibrio cholerae infections: proposed mechanisms of pathogenesis and antibacterial immunity.

机译：霍乱弧菌感染中霍乱生物的分布：提出的发病机理和抗菌免疫机制。

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摘要

This study was undertaken to determine the sequence of events in the microenvironment of the intestinal tract that culminate in the symptoms of cholera and to attempt to define more clearly the mechanisms involved in antibacterial immunity. The extent to which mucus occurs in the normal intestine of rabbits and the appearance of the intestinal villi in unfixed frozen sections was demonstrated. The villi and intervillous spaces were found to be normally covered by a layer of mucoid material that formed a mucous zone between the intestinal contents and the tips of the villi. The distribution of cholera organisms in normal and immunized animals was demonstrated by the staining of frozen-tissue sections with specific fluorescent antibody. Study of tissue sections from normal animals showed that the onset of fluid accumulation was concomitant with the establishment of large masses of organisms in the intervillous spaces and crypts of the intestine after the successful penetration of this mucous zone. Tissue sections from animals actively or passively immunized against a cell wall antigen of Vibrio cholerae showed clumping of vibrios in the lumen and restricted distribution in the lumen and luminal border of the mucous zone. Antibody was not lytic in vivo.
机译：进行这项研究是为了确定在肠道微环境中最终导致霍乱症状的事件顺序，并试图更清楚地定义参与抗菌免疫的机制。证实了在兔的正常肠中粘液发生的程度以及未固定的冷冻切片中肠绒毛的出现。发现绒毛和绒毛间间隙通常被一层粘液样物质覆盖，该粘液样物质层在肠内容物和绒毛尖端之间形成了粘液区。霍乱生物在正常和免疫动物中的分布通过用特异性荧光抗体对冷冻组织切片进行染色来证明。对正常动物组织切片的研究表明，成功穿透该粘膜区后，在小肠间隙和肠腔内大量积聚生物体伴随着积液的开始。对霍乱弧菌的细胞壁抗原进行主动或被动免疫的动物的组织切片显示，内腔弧菌成团，在粘液区的内腔和腔腔边界分布受限。抗体在体内不溶。

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