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首页> 外文期刊>Infection and immunity >Antibody-dependent cellular protection against herpes simplex virus dissemination as revealed by viral plauqe and infectivity assays.
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Antibody-dependent cellular protection against herpes simplex virus dissemination as revealed by viral plauqe and infectivity assays.

机译：病毒性感染和感染性测定揭示了针对单纯疱疹病毒传播的抗体依赖性细胞保护作用。

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Mouse nonimmune peripheral blood lymphocytes (PBL) plus antibody to herpes simplex virus inhibited virus dissemination in herpes simplex virus-infected 3T3 cell culture as revealed by development of viral plaque, size of immunofluorescent foci, appearance of polycaryocytes, and viral infectivity appearing in the culture. These nonimmune PBL did not act alone in inibiting virus dissemination, but did act synergistically in combination with antibody. The ratio of PBL to target monolayer cells needed to produce this effect was 20. Splenic lymphocytes had weak activity, whereas thymocytes were without effect, even in the presence of antibody. Neither interferon nor lymphotoxin was detected in this lymphocyte-mediated response. These findings support previous observations, based on cytotoxicity assays, that antibody-dependent cellular immune processes could be important in control of and recovery from herpesvirus infection.
机译：小鼠非免疫性外周血淋巴细胞（PBL）加上抗单纯疱疹病毒的抗体抑制了单纯疱疹病毒感染的3T3细胞培养物中的病毒传播，如病毒斑的形成，免疫荧光灶的大小，多核细胞的出现以及培养物中出现的病毒感染性所揭示。这些非免疫性PBL在抑制病毒传播中并不单独发挥作用，但与抗体协同作用。产生这种作用所需的PBL与靶单层细胞的比例为20。脾脏淋巴细胞的活性较弱，而胸腺细胞即使在存在抗体的情况下也没有作用。在这种淋巴细胞介导的反应中未检测到干扰素或淋巴毒素。这些发现支持以前基于细胞毒性测定的观察结果，即依赖抗体的细胞免疫过程对于控制疱疹病毒感染和从中恢复很重要。

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