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Phytohemagglutinin enhancement of dengue-2 virus replication in nonimmune rhesus monkey peripheral blood leukocytes.

机译:植物血凝素增强非免疫恒河猴外周血白细胞中登革2病毒复制的能力。

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Phytohemagglutinin treatment of peripheral blood leukocytes from dengue nonimmune monkeys enhanced dengue-2 virus replication. Enhancement was due primarily to an increase in the number of infected cells. Destruction of mononuclear phagocytes with silica did not significantly inhibit virus replication in phytohemagglutinin-treated cultures. Pokeweed mitogen, concanavalin A, and streptolysin O stimulated increased deoxyribonucleic acid synthesis in monkey leukocytes but did not enhance virus replication. None of the mitogens significantly affected virus replication in cultures of dengue-immune monkey peripheral blood leukocytes.
机译:植物血凝素治疗登革热非免疫猴子的外周血白细胞增强了登革2病毒的复制。增强主要是由于感染细胞数量的增加。用二氧化硅破坏单核吞噬细胞并没有显着抑制植物血凝素处理过的培养物中的病毒复制。商陆有丝分裂原,伴刀豆球蛋白A和链球菌溶血素O刺激了猴白细胞中脱氧核糖核酸合成的增加,但并未增强病毒复制。在登革热免疫猴外周血白细胞培养物中,丝裂原均无显着影响病毒复制。

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