Cryptic peptidoglycan and the antiphagocytic effect of the Staphylococcus aureus capsule: model for the antiphagocytic effect of bacterial cell surface polymers.

B J Wilkinson; P K Peterson; P G Quie

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Cryptic peptidoglycan and the antiphagocytic effect of the Staphylococcus aureus capsule: model for the antiphagocytic effect of bacterial cell surface polymers.

机译：隐秘肽聚糖和金黄色葡萄球菌胶囊的抗吞噬作用：细菌细胞表面聚合物抗吞噬作用的模型。

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The antiphagocytic effect of the Staphylococcus aureus capsule is known to be related to its ability to interfere with opsonization by normal human serum. In this study, evidence is presented with isolated cell surface components which indicates that the capsule hinders opsonization by masking cell wall peptidoglycan. In contrast to intact, encapsulated S. aureus M cells, peptidoglycan particles isolated from the organism were efficiently opsonized by normal human serum and phagocytized by human polymorphonuclear leukocytes. Cell wall particles retaining capsular material were opsonized less efficiently than peptidoglycan. Studies comparing the opsonic capacities of normal, C2-deficient, and heat-inactivated sera led to the conclusion that both the classical and the alternative complement pathways contribute to the opsonization of peptidoglycan in normal human serum. It appears that the capsule interferes with opsonization via both of these complement pathways. Serum from rabbits immunized with S. aureus M had significant heat-stable opsonic activity for the intact organism and cell walls retaining capsular material, but not for peptidoglycan. A general model is proposed to explain how antiphagocytic cell surface polymers may inhibit bacterial opsonization and thereby impede natural immunity.

机译：已知金黄色葡萄球菌胶囊的抗吞噬作用与其通过正常人血清干扰调理作用的能力有关。在这项研究中，有证据表明分离的细胞表面成分表明该胶囊通过掩盖细胞壁肽聚糖而阻碍调理作用。与完整的封装金黄色葡萄球菌M细胞相反，从生物体中分离出的肽聚糖颗粒可通过正常人血清有效调理，并通过人多形核白细胞吞噬。保留胶囊材料的细胞壁颗粒的调理作用比肽聚糖低。比较正常，C2缺乏和热灭活血清的调渗能力的研究得出的结论是，经典和替代补体途径均能促进正常人血清中肽聚糖的调理作用。看来胶囊通过这两种补体途径干扰调理作用。用金黄色葡萄球菌M免疫的兔子的血清对完整的有机体和保留荚膜物质的细胞壁具有显着的热稳定调理活性，而对肽聚糖则没有。提出了一个通用模型来解释抗吞噬细胞表面聚合物如何抑制细菌调理作用，从而阻碍自然免疫。

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《Infection and immunity》 |1979年第2期|共7页
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B J Wilkinson; P K Peterson; P G Quie;
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1. Staphylococcus aureus Serotype 5 Capsular Polysaccharide Is Antiphagocytic and Enhances Bacterial Virulence in a Murine Bacteremia Model [J] . Manoj Thakker, Jin-Sir Park, Vincent Carey, Infection and immunity . 1998,第11期

机译：金黄色葡萄球菌血清型5荚膜多糖是抗吞噬作用，并增强小鼠细菌血症模型中的细菌毒力。
2. Inhibition of Cell Surface Export of Group A Streptococcal Anchorless Surface Dehydrogenase Affects Bacterial Adherence and Antiphagocytic Properties [J] . Grégory Bo?l, Hong Jin, Vijay Pancholi Infection and immunity . 2005,第10期

机译：A组链球菌无锚表面脱氢酶细胞表面出口的抑制影响细菌粘附和抗吞噬性能。
3. Inhibition of Cell Surface Export of Group A Streptococcal Anchorless Surface Dehydrogenase Affects Bacterial Adherence and Antiphagocytic Properties [J] . Grégory Bo?l, Hong Jin, Vijay Pancholi Infection and immunity . 2005,第10期

机译：A组链球菌无锚表面脱氢酶细胞表面出口的抑制影响细菌粘附和抗吞噬性能。
4. STRUCTURAL AND MECHANISTIC BASIS FOR THE O-ACETYLATION OF PEPTIDOGLYCAN BY THE VIRULENCE FACTORS PatB OF Neisseria gonorrhoeae AND OatA FROM BOTH Staphylococcus aureus AND Streptococcus pneumoniae. [C] . Anthony J. Clarke, David Sychantha, Ashley Brott International Carbohydrate Symposium . 2018

机译：肽聚糖的结构和机械基础，肽因子毒力因子刺痛的因子和来自金黄色葡萄球菌的葡萄球菌和肺炎链球菌肺炎链球菌的毒性因子。
5. Influence of in vitro bacterial urokinase responsiveness on the in vivo pathogenesis of methicillin-sensitive Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in mouse models. [D] . Yanke, Shawna Janine. 2000

机译：体外细菌尿激酶反应性对小鼠模型中甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林的金黄色葡萄球菌的体内发病机理的影响。
6. Cryptic peptidoglycan and the antiphagocytic effect of the Staphylococcus aureus capsule: model for the antiphagocytic effect of bacterial cell surface polymers. [O] . B J Wilkinson, P K Peterson, P G Quie 1979

机译：隐秘肽聚糖和金黄色葡萄球菌胶囊的抗吞噬作用：细菌细胞表面聚合物的抗吞噬作用模型。
7. Inhibition of Cell Surface Export of Group A Streptococcal Anchorless Surface Dehydrogenase Affects Bacterial Adherence and Antiphagocytic Properties [O] . Boël, Grégory, Jin, Hong, Pancholi, Vijay 2005

机译：A组链球菌无锚表面脱氢酶细胞表面出口的抑制影响细菌粘附和抗吞噬性能。

Cryptic peptidoglycan and the antiphagocytic effect of the Staphylococcus aureus capsule: model for the antiphagocytic effect of bacterial cell surface polymers.

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