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首页> 外文期刊>Infection and immunity >Activity of Minocycline Against R Factor-Carrying Enterobacteriaceae
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Activity of Minocycline Against R Factor-Carrying Enterobacteriaceae

机译：米诺环素对携带R因子的肠杆菌科的活性

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Minocycline (Min) and other tetracyclines were tested in vivo and in vitro for activity against strains of salmonellae harboring R factor-mediated chlortetracycline (A) resistance. Minocycline was more active in vitro against these strains than the other tetracyclines. Mice infected with these cultures responded to treatment with Min, but there was little or no response to treatment with the other tetracyclines. Various A-resistant field isolates of Salmonella typhimurium and Escherichia coli were all shown to be more susceptible in vitro to Min than to A. Several of these cultures were shown to transfer A resistance. Cultures of normal bacterial flora were isolated from swine fecal matter after plating on Min-supplemented Mac-Conkey agar. All recovered cultures were more susceptible in vitro to Min than to A. Several isolates were able simultaneously to transfer Min and A resistances into S. choleraesuis var. kunzendorf; however, the levels of Min resistance in either the donors or exconjugants were no higher than in those cultures of salmonellae which responded in vivo to Min therapy. The same was true for the levels of Min resistance in the field isolates of S. typhimurium and E. coli. The increased potency of Min, as compared to tetracycline, against R factor-carrying bacteria was not observed for organisms made resistant (presumably chromosomally) to A by successive transfers in increasing concentrations of the agent, suggesting different mechanisms as the basis for chromosomal versus R factor-mediated A resistances.
机译：在体内和体外测试了米诺环素（Min）和其他四环素对沙门氏菌对具有R因子介导的金霉素（A）耐药性的菌株的活性。美诺环素在体外对这些菌株的活性高于其他四环素。感染了这些培养物的小鼠对Min的治疗反应良好，但对其他四环素的治疗却几乎没有反应。鼠伤寒沙门氏菌和大肠杆菌大肠埃希菌的各种A耐药菌株在体外对Min的敏感性均高于对A的敏感性。这些培养物中的几种已证明可转移A抵抗性。在最小补充Mac-Conkey琼脂上铺板后，从猪粪中分离出正常细菌菌群的培养物。在体外，所有回收的培养物对Min的敏感性都比对A的敏感性高。几种分离株能够同时将Min和A的抗性转移到 S中。霍乱弧菌 var。 kunzendorf ;但是，供体或准分子的最小抗药性水平不高于那些对最小疗法在体内有反应的沙门氏菌培养物。对于 S田间分离株中的最低抗性水平也是如此。鼠伤寒和 E。大肠杆菌。与四环素相比，通过连续增加浓度的药剂对A产生抗药性（推测是对染色体有抵抗力）的生物，未观察到Min增强了对R因子携带细菌的抵抗力，表明了不同的机制作为染色体相对于R的基础因子介导的A抗性。

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