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Induction of Interferon in L Cells by Reoviruses

机译：呼肠孤病毒在L细胞中诱导干扰素

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L cell cultures challenged with reoviruses types 1 and 3 produced little to no detectable interferon under conditions which permitted virus replication and under conditions which prevented replication of a temperature-sensitive mutant strain of reovirus type 3 (ts-1). Ultraviolet-irradiated reoviruses and double-stranded ribonucleic acids extracted from purified reovirus type 3 also induced little to no interferon in L cell cultures. Under similar conditions, MM virus proved to be an effective inducer of interferon. Exposure of L cells to interferon prior to challenge with virus (priming) failed to enhance interferon production upon subsequent challenge with reovirus although priming increased the amount of interferon produced following MM virus challenge. L cell cultures that were challenged with reovirus type 3 and subsequently with either MM or Colorado tick fever viruses produced similar titers of interferon as cell cultures that were challenged with either MM or Colorado tick fever virus alone, respectively. These data show that the presence of production of reovirus type 3 double-stranded ribonucleic acid is not sufficient for induction of interferon in L cell cultures and that additional processes which are required for induction of interferon in L cell cultures are not expressed by reovirus type 3.
机译：用1型和3型呼肠孤病毒攻击的L细胞培养物在允许病毒复制的条件下和阻止3型呼肠孤病毒的温度敏感突变株（ts-1）复制的条件下几乎不产生甚至检测不到干扰素。紫外线照射的呼肠孤病毒和从3型纯化呼肠孤病毒中提取的双链核糖核酸在L细胞培养物中也几乎不产生干扰素。在类似条件下，MM病毒被证明是有效的干扰素诱导剂。尽管随后的呼肠孤病毒引发了MM病毒攻击，但初免增加了干扰素产生的干扰素的量，但在随后的呼肠孤病毒攻击后，L细胞暴露于干扰素（初免）后仍无法增强干扰素的产生。分别用3型呼肠孤病毒和随后的MM或Colorado壁虱热病毒攻击的L细胞培养物产生的滴度与单独使用MM或Colorado壁虱热病毒攻击的细胞培养物相似。这些数据表明，呼肠孤病毒3型双链核糖核酸的产生不足以在L细胞培养物中诱导干扰素，并且呼肠孤病毒3型不表达在L细胞培养物中诱导干扰素所需的其他过程。 。

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