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首页> 外文期刊>Infection and immunity >Cytotoxicity of rat macrophages activated by persistent or biodegradable bacterial cell walls.
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Cytotoxicity of rat macrophages activated by persistent or biodegradable bacterial cell walls.

机译：持续或可生物降解的细菌细胞壁激活的大鼠巨噬细胞的细胞毒性。

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Peritoneal macrophages from Fischer 344 rats were cytotoxic for mouse fibroblasts after in vitro phagocytosis of non-biodegradable group A streptococcal cell walls. In contrast, macrophages from Buffalo rats were not activated to cytotoxicity by bacterial cell walls. Activation to cytotoxicity was only achieved by the macrophages after an interval of at least 3 days in culture after ingestion of group A cell walls. If macrophages were cultured only 24 h after ingestion of cell walls, a cytostatic effect on target cells was observed. Phagocytosis of biodegradable group D streptococcal cell walls did not activate macrophages from either rat strain to become cytotoxic. No direct toxicity of cell walls for macrophages or mouse L-cells was observed. The cytotoxicity of Fischer 344 macrophages appears to require direct cell contact with target cells.
机译：在体外吞噬不可生物降解的A组链球菌细胞壁后，来自Fischer 344大鼠的腹膜巨噬细胞对小鼠成纤维细胞具有细胞毒性。相反，来自布法罗大鼠的巨噬细胞没有被细菌细胞壁激活为细胞毒性。吞噬A组细胞壁后，在培养中至少间隔3天后，巨噬细胞才能激活细胞毒性。如果巨噬细胞在摄取细胞壁后仅24小时培养，则观察到对靶细胞有抑制细胞作用。可生物降解的D组链球菌细胞壁的吞噬作用不会激活任何一种大鼠品系的巨噬细胞，使其具有细胞毒性。没有观察到细胞壁对巨噬细胞或小鼠L细胞的直接毒性。 Fischer 344巨噬细胞的细胞毒性似乎要求细胞直接与靶细胞接触。

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