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首页> 外文期刊>Infection and immunity >New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis.
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New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis.

机译：支原体诱发的兔慢性滑膜炎的新模型：注射了关节炎支原体和肺炎支原体的兔子的微生物学，组织病理学和免疫学观察。

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A dose-dependent chronic synovitis was induced in rabbit knees after the intra-articular injection of both Mycoplasma arthritidis and Mycoplasma pulmonis. The inflammation progressed from an initial acute phase at 1 week characterized by edema, infiltration of the synovium with monocytes and heterophils, and desquamation of lining cells, to a more chronic phase at 1 and 3 months, in which villus hyperplasia, lymph "nodules," mononuclear cell infiltration, fibroplasia, and collagen deposition were prominent. With one exception, mycoplasmas could no longer be cultivated from the joints 1 month postinoculation. Both mycoplasma species evoked a humoral antibody response that was more marked in synovial fluids than in peripheral blood. A cell-mediated immune reaction, as evidence by enhanced uptake by [3H]thymidine by sensitized blood, spleen, or node lymphocytes in the presence of homologous antigen, was detected only in rabbits injected with M. pulmonis. Lymphocytes taken from arthritic rabbits were no more cytotoxic toward synovial cells derived from normal or arthritic rabbits than were normal lymphocytes. The models of synovitis described in this study offer a convenient probe for determining the mechanisms of mycoplasma-induced inflammation, since they require only a single injection of the initiating agent and, in addition, utilize an animal host large enough for detailed investigation into the nature of mycoplasma/synovium interactions.
机译：关节内注射支原体和肺炎支原体后，在兔膝盖中诱发了剂量依赖性慢性滑膜炎。炎症从1周的初期急性期发展为1月和3个月，初期为急性期，该期以水肿，滑膜被单核细胞和异源性细胞浸润，衬里细胞脱屑为特征，逐渐发展为更慢性的阶段，即绒毛增生，淋巴结节，单核细胞浸润，纤维化和胶原蛋白沉积是突出的。除一个例外，接种后1个月不能再从关节上培养支原体。两种支原体都引起体液抗体反应，在滑液中比在外周血中更明显。仅在注射肺炎支原体的兔子中才检测到细胞介导的免疫反应，这是通过在同源抗原存在下敏化的血液，脾脏或结节淋巴细胞对[3H]胸苷的摄取增强所证明的。取自关节炎兔的淋巴细胞对源自正常或关节炎兔的滑膜细胞的细胞毒性不大于正常淋巴细胞。这项研究中描述的滑膜炎模型为确定支原体诱发的炎症机制提供了一种方便的探针，因为它们仅需注射一次引发剂，并且利用足够大的动物宿主来详细研究自然界支原体/滑膜间相互作用的关系。

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