Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics

B. C. Cole; J. R. Ward; R. S. Jones; J. F. Cahill

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Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics

机译：关节炎支原体诱导的小鼠慢性增生性关节炎I.疾病的诱导和组织病理学特征

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Mice injected intravenously with Mycoplasma arthritidis developed a chronic arthritis which persisted through at least 269 days. Rats similarly treated developed an acute short-term infection. The mouse disease was characterized by periods of remission and exacerbation and was proliferative in nature, gradually spreading to adjacent joints. M. arthritidis strain 158 P10 was found to be less arthritogenic for mice than for rats, but further passage of this strain in mice substantially increased its virulence. Unlike rats, mice appeared to be susceptible to a “toxin” of M. arthritidis and they developed a necrotic spreading abscess after subcutaneous administration of the organisms. Histopathological studies revealed that mice varied greatly in the degree of joint inflammation, destruction, and repair. The disease was characterized by (i) an initial acute phase with infiltration of the articular and periarticular tissues with polymorphonuclear leukocytes and a mild hyperplasia of the synovial membrane; (ii) a mixed acute-chronic phase in which new areas of acute inflammation developed alongside areas of chronic lesions; (iii) a chronic phase followed which was characterized by massive synovial proliferation with mononuclear cell infiltration, irregularity in the articulating cartilage, pannus formation, and “punched out” defects in cortical bone near cartilagenous osseous junctures. The clinical course and histopathological characteristics of the chronic phase of mouse arthritis induced by M. arthritidis closely resembled those of rheumatoid arthritis of man.

机译：静脉注射支原体的小鼠发展成为一种慢性关节炎，至少持续269天。接受类似治疗的大鼠发展为急性短期感染。小鼠疾病的特征在于缓解和加重期，并且本质上是增殖性的，逐渐扩散到相邻的关节。 M。人们发现关节炎小鼠158 P10的致关节炎作用不及大鼠，但该菌株在小鼠中的进一步传代大大提高了其毒力。与大鼠不同，小鼠似乎对 M的“毒素”敏感。皮下注射生物体后，关节炎发展为坏死性扩散脓肿。组织病理学研究表明，小鼠的关节炎症，破坏和修复程度差异很大。该疾病的特征是：（i）初始急性期，多形核白细胞浸润关节和关节周围组织，滑膜轻度增生。（ii）急性-慢性混合阶段，其中新的急性炎症区域与慢性病变区域一起发展; （iii）慢性期，其特征在于滑膜大量增生，单核细胞浸润，关节软骨不规则，pan团形成，以及在软骨骨连接点附近的皮质骨“穿孔”。 M诱发的小鼠关节炎慢性期的临床过程和组织病理学特征。关节炎与人的类风湿关节炎非常相似。 展开▼

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《Infection and immunity》 |1971年第4期|共12页

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B. C. Cole; J. R. Ward; R. S. Jones; J. F. Cahill;
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专利

1. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro. [J] . B C Cole, L Golightly-Rowland, J R Ward Infection and immunity . 1975,第5期

机译：由关节炎支原体引起的小鼠的慢性增生性关节炎：体外证明细胞介导的对支原体抗原的免疫反应。

2. Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis II. Serological Responses of the Host and Effect of Vaccines [J] . B. C. Cole, J. R. Ward, L. Golightly-Rowland, Infection and immunity . 1971,第4期

机译：关节炎支原体II诱导的小鼠慢性增生性关节炎。宿主的血清学反应和疫苗的作用

3. New models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with Mycoplasma arthritidis and Mycoplasma pulmonis. [J] . B C Cole, M M Griffiths, E J Eichwald, Infection and immunity . 1977,第1期

机译：支原体诱发的兔慢性滑膜炎的新模型：注射了关节炎支原体和肺炎支原体的兔子的微生物学，组织病理学和免疫学观察。

4. A COMPARATIVE STUDY BETWEEN THE PREVENTIVE USE OF TILMICOSIN PHOSPHATE (PULMOTIL PREMIX~(R)) AND MYCOPLASMA HYOPNEUMON1AE VACCINATION IN A PIG HERD WITH CHRONIC RESPIRATORY DISEASE [C] . B. Mateusen, D. Maes, E. De Ridder, Congress of the International Pig Veterinary Society . 2000

机译：患有慢性呼吸道疾病的猪群中预防性用途（Pulmotil Premix〜（R））和支原体蜂猴疫苗接种的比较研究

5. Evaluation of the mode of action and human relevance of peroxisome proliferator activated receptor gamma agonist-induced hemangiosarcomas in mice. [D] . Kakiuchi-Kiyota, Satoko. 2010

机译：评价过氧化物酶体增殖物激活受体γ激动剂诱导的小鼠血管肉瘤的作用方式和人类相关性。

6. Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics [O] . B. C. Cole, J. R. Ward, R. S. Jones, 1971

机译：关节炎支原体诱导的小鼠慢性增生性关节炎I.疾病的诱导和组织病理学特征

7. Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro [O] . B C Cole, L Golightly-Rowland, J R Ward 1975

机译：支原体诱导的小鼠慢性增殖关节炎：在体外证明细胞介导的药物抗原的免疫应答

8. The Occurrence of 'Mycoplasma Arthritidis' in the Throat and Middle Ear of Rats with Chronic Respiratory Disease. [R] . Stewart, D. D., Buck, G. E. 1975

机译：慢性呼吸系统疾病大鼠咽喉和中耳“关节炎支原体”的发生。

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1. 提高2C-like细胞的小鼠胚胎干细胞诱导培养液及小鼠胚胎干细胞诱导培养方法 [P] . 中国专利： CN110804581A . 2020-02-18

2. 小鼠近视模型的诱导装置、诱导方法以及小鼠近视模型 [P] . 中国专利： CN103598143A . 2014-02-26

3. Compound pharmaceutical compound and processes to antagonize endothelin to treat hypertension congestive heart failure restenosis following arterial lesion cerebral or myocardial ischemia or atherosclerosis coronary angina cerebral vasospasm acute renal failure and chronic gastric ulceration cyclosporine-induced nephrotic toxicity endotoxin-induced endotoxin-induced toxicity by endotoxin with lpl proliferative diseases acute pulmonary hypertension or chronic platelet aggregation tombose cardiotoxicity mediated by il-2 nonciception colitis disorder of vascular permeabulity lesion by reperfusion-ischemia deraynaud disease and migraine and to prepare a compound. [P] . 外国专利： BR9707509A . 1999-07-27

机译：拮抗内皮素的复合药物化合物和方法，可治疗动脉病变脑或心肌缺血或动脉粥样硬化后的高血压充血性心力衰竭再狭窄冠心绞痛脑血管痉挛急性肾衰竭和慢性胃溃疡环孢素诱导的肾病毒性内毒素诱导的内毒素诱导的毒性lpl增生性疾病急性肺动脉高压或慢性血小板聚集性tombose心脏毒性是由il-2介导的非渗透性皮炎病灶和再灌注缺血性偏头痛所致的il-2非感受性结肠炎疾病所介导的。

4. compound for use in the manufacture of a medicament for reducing the symptoms of a disease selected from the group consisting of muscular dystrophy, arthritis, craniocerebral trauma, spinal cord injury, sepsis, rheumatic disease, cancer atherosclerosis, type 1 diabetes, type 2 diabetes, leptospirosis kidney disease, glaucoma, retinal disease, aging, headache, aches, complex regional pain syndrome, cardiac hypertrophy, muscle wasting, catabolic disorders, obesity, fetal growth retardation, hypercholesterolemia, heart disease, chronic heart failure, ischemia / reperfusion, stroke, cerebral aneurysm, angina pectoris, lung disease, cystic fibrosis, acid-induced lung injury, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, sjogren's syndrome, hyaline membrane disease, kidney disease, glomerular disease, liver disease alcohol, bowel diseases, peritoneal endometriosis, skin diseases and, nasal sinusitis, mesothelioma, anhidrotic ecodermal dysplasia-id, behcet's disease, [P] . 外国专利： BRPI0909564A2 . 2015-09-22

机译：用于制造减轻疾病症状的药物的化合物，所述疾病选自肌肉营养不良，关节炎，颅脑外伤，脊髓损伤，败血症，风湿性疾病，癌症动脉粥样硬化，1型糖尿病，2型糖尿病，钩端螺旋体病肾脏疾病，青光眼，视网膜疾病，衰老，头痛，疼痛，复杂的局部疼痛综合征，心脏肥大，肌肉消瘦，分解代谢异常，肥胖，胎儿发育迟缓，高胆固醇血症，心脏病，慢性心力衰竭，缺血/再灌注，中风，脑动脉瘤，心绞痛，肺部疾病，囊性纤维化，酸引起的肺损伤，肺动脉高压，哮喘，慢性阻塞性肺疾病，干燥综合征，透明膜疾病，肾脏疾病，肾小球疾病，酒精中毒，肠病，腹膜子宫内膜异位症，皮肤疾病和鼻窦炎，间皮瘤，缺汗的生态皮肤异型增生，白塞病，

5. Compound, pharmaceutical composition, use of a compound, and, methods for the treatment and / or prophylaxis of asthma, allergy, arthritis, including rheumatoid arthritis and spondyloarthritis, gout, atherosclerosis, chronic inflammatory bowel disease (crohn's disease), inflammatory dermatological disorders and proliferative, psoriasis, atopic dermatitis, uveitis, septic shock, AIDS and osteoporosis and for the treatment of acne [P] . 外国专利： BR0016164A . 2002-08-13

机译：化合物，药物组合物，化合物的用途以及治疗和/或预防哮喘，过敏，关节炎（包括类风湿关节炎和脊椎关节炎），痛风，动脉粥样硬化，慢性炎性肠病（克罗恩病），炎性皮肤病和增生，牛皮癣，特应性皮炎，葡萄膜炎，败血性休克，艾滋病和骨质疏松症以及痤疮的治疗

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Chronic Proliferative Arthritis of Mice Induced by Mycoplasma arthritidis I. Induction of Disease and Histopathological Characteristics

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