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首页> 外文期刊>Infection and immunity >Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified 987 or K99 pili: protection correlates with pilus homology of vaccine and challenge.
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Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified 987 or K99 pili: protection correlates with pilus homology of vaccine and challenge.

机译：通过用纯化的987或K99菌毛接种大坝为乳猪免疫肠道毒素性大肠杆菌引起的腹泻病：保护作用与疫苗的菌毛同源性和挑战性相关。

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Pregnant gilts were vaccinated with purified strain 987 pili (987P), strain K99 pili, or a saline-formaldehyde control. Suckling pigs born to vaccinated gilts were allowed to consume colostrum and were then challenged intragastrically with one of three enterotoxigenic Escherichia coli strains: 987 (O9:K103, 987P:NM), 74-5208 (02O:K101, 987P:NM) or 431 (O101:K30, 99:NM). In litters where the dam was vaccinated with the same pilus as that possessed by the challenge organism, the incidence and duration of diarrhea and the degree of intestinal colonization (either duration or extent) were less than those of the other vaccine groups. Surviving pigs in the homologous vaccine groups also had better weight gains than pigs in the other vaccine groups. The experiments extend and confirm previous reports that vaccination of the dam with purified pili confers protection to neonatal suckling pigs against diarrheal disease caused by enterotoxigenic E. coli strains that possess the same pili. Protection did not extend to enterotoxigenic strains possessing different pili.
机译：用纯种987 pili（987P），K99 pili菌株或生理盐水-甲醛对照对怀孕的小母猪进行疫苗接种。接种了后备母猪的乳猪被允许食用初乳，然后用三种产肠毒素的大肠埃希氏菌菌株之一挑战胃内：987（O9：K103，987P：NM），74-5208（02O：K101、987P：NM）或431 （O101：K30，99：NM）。在大坝中接种了与攻击生物体相同的菌毛的仔猪中，腹泻的发生率和持续时间以及肠道菌落的程度（持续时间或程度）低于其他疫苗组。同源疫苗组中存活的猪的体重增加也比其他疫苗组中的猪更好。实验扩展并证实了先前的报道，即用纯菌毛对大坝进行疫苗接种可保护新生乳猪免受由具有相同菌毛的产肠毒素大肠杆菌菌株引起的腹泻病的侵害。保护作用不扩展到具有不同菌毛的产毒菌株。

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