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首页> 美国政府科技报告 >Immunologic Control of Diarrheal Disease due to Enterotoxigenic Escherichia coli: Reactogenicity, Immunogenicity, and Efficacy Studies of Purified Escherichia coli H10407 Type 1 Somatic Pili Vaccine.
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Immunologic Control of Diarrheal Disease due to Enterotoxigenic Escherichia coli: Reactogenicity, Immunogenicity, and Efficacy Studies of Purified Escherichia coli H10407 Type 1 Somatic Pili Vaccine.

机译：产肠毒素大肠杆菌引起的腹泻病的免疫控制：纯化的大肠杆菌H10407 1型体细胞疫苗的反应原性，免疫原性和功效研究。

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Priority tasks in the 1980 contract year were as follows: (1) to develop an immunogenic, non-reactogenic two dose parenteral immunization schedule that would stimulate brisk anti-pili antibody responses without causing adverse reactions. With development of such an immunization procedure, further efficacy challenge studies could proceed. (2) challenge studies to assess the efficacy of the new, non-reactogenic two-dose immunization schedule. (3) more detailed investigation of the circulating O antibody response noted to occur following primary immunization of volunteers with type 1 somatic pilus vaccine. (4) further studies to assess the frequency of occurence of CFA/I, CFA/II and type 1 somatic pili in ETEC pathogens from diverse geographic sources. Development of a Non-Reactogenic Immunogenic Two-Dose Immunization Schedule for Type 1 Somatic Pilus Vaccine Reactogenicity.

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