...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Enteric Immunization with Live Adenovirus Type 21 Vaccine II. Systemic and Local Immune Responses Following Immunization
【24h】

Enteric Immunization with Live Adenovirus Type 21 Vaccine II. Systemic and Local Immune Responses Following Immunization

机译：用21型活腺病毒疫苗进行肠内免疫。免疫后的全身和局部免疫反应

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Studies of the immunologic responses following administration of a live, enteric-coated adenovirus (ADV) type 21 vaccine showed that nine of ten vaccinees and none of five controls developed neutralizing antibody. Antibody activity of serum and secretory immunoglobulins was assayed by using a 14C-labeled ADV-21 antigen in a radioimmunodiffusion system. Increases in immunoglobulin M, A and G (IgM, IgA, IgG) activity were detected in sera from vaccinees but not in those from controls. IgA copro antibody activity was also shown in vaccinees but not in controls. Nasal secretions showed no detectable IgA antibody responses by this method. These studies show marked differences in serum and local IgA antibody activity in induced enteric ADV infection compared to previously reported responses after natural infection. The protective role of secretory IgA in adenovirus infections is obscure. However, absence of nasal IgA responses may indicate that protection against disease with enteric ADV vaccines depends primarily upon humoral antibody.
机译：接种活的，肠溶衣的21型腺病毒（ADV）疫苗后的免疫反应研究表明，十种疫苗中的九种疫苗和五种对照中没有一种会产生中和抗体。在放射免疫扩散系统中使用 14 C标记的ADV-21抗原测定血清和分泌性免疫球蛋白的抗体活性。在被疫苗接种者的血清中检测到免疫球蛋白M，A和G（IgM，IgA，IgG）的活性增加，但在对照小鼠的血清中未检测到。 IgA copro抗体活性也显示在疫苗中，但未在对照中显示。鼻分泌物显示通过这种方法没有可检测的IgA抗体应答。这些研究表明，与先前报道的自然感染后的反应相比，诱导的肠ADV感染的血清和局部IgA抗体活性存在明显差异。分泌型IgA在腺病毒感染中的保护作用是模糊的。但是，如果没有鼻IgA反应，可能表明用肠ADV疫苗预防疾病的方法主要取决于体液抗体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号