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首页> 外文期刊>Infection and immunity >Effects of Purified Staphylococcal Alpha Toxin on the Ultrastructure of Human and Rabbit Erythrocytes
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Effects of Purified Staphylococcal Alpha Toxin on the Ultrastructure of Human and Rabbit Erythrocytes

机译：纯化的葡萄球菌α毒素对人和兔红细胞超微结构的影响

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Previous studies have suggested that the primary site of action of purified staphylococcal alpha toxin is the cell membrane. Scanning and transmission electron microscopy studies were undertaken, therefore, to define toxin-induced alterations in the surface morphology of rabbit and human red blood cells. During the prelytic lag phase, scanning electron microscopy revealed multiple discrete blisters on the surface of rabbit red blood cells; during hemolysis, cellular collapse and ghosts were seen, but most striking was the separation of large fragments of cell membrane from red blood cell surfaces. In contrast, alterations in less sensitive human red blood cells were limited to occasional fingerlike protrusions during the period of accelerated lysis. Transmission electron microscopy substantiated these changes. These studies have provided further evidence that the cell membrane is the primary site of action of staphylococcal alpha toxin.
机译：先前的研究表明，纯化的葡萄球菌α毒素的主要作用部位是细胞膜。因此，进行了扫描和透射电子显微镜研究，以定义毒素诱导的兔和人红细胞表面形态的变化。在溶血性滞后阶段，扫描电镜观察到兔子红细胞表面有多个离散的水泡。在溶血过程中，可以看到细胞崩溃和重影，但最引人注目的是从红细胞表面分离出大的细胞膜碎片。相反，在加速裂解期间，不太敏感的人类红细胞的变化仅限于偶发的手指状突起。透射电子显微镜证实了这些变化。这些研究提供了进一步的证据，表明细胞膜是葡萄球菌α毒素的主要作用部位。

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