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首页> 外文期刊>Infection and immunity >Growth and immunogenicity of photochromogenic strains of mycobacteria in the footpads of normal mice.
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Growth and immunogenicity of photochromogenic strains of mycobacteria in the footpads of normal mice.

机译：正常小鼠脚垫中分枝杆菌光致变色菌株的生长和免疫原性。

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Specific pathogen-free CD-1 mice were infected subcutaneously in the footpad with mycobacterium kansasii, three strains of M. marinum, and two strains of M. simiae-habana, and the growth of the organisms in the footpad, the draining popliteal lymph node, and the lung and spleen was followed quantitatively for up to 60 days. The ability of a footpad inoculum of M. marinum to spread to the lungs and spleen correlated with the ability of the organism to survive and multiple at 37 C in vitro cultures. The amount of footpad swelling which developed in the M. kansasii- and M. marinum-infected mice varied depending upon the strain of organism and the size of the original footpad inoculum. Injection of dead M. marinum into the footpad also induced an extensive amount of swelling which varied with the strain used, as well as being dose dependent. M. marinum- and BCG-vaccinated mice were protected against a later footpad challenge with M. marinum or the highly mouse virulent M. tuberculosis strain ERDMAN. The significance of this finding is discussed in relation to cross-protection studies using a variety of mycobacteria in the footpad infection model.
机译：将不含特定病原体的CD-1小鼠皮下感染堪萨斯分枝杆菌，三株海藻分枝杆菌和两株simiae-habana株，并使其在足垫皮下感染，并在足垫，排水的pop部淋巴结中生长生物。 ，并定量跟踪肺和脾长达60天。海藻分枝杆菌的足垫接种物扩散到肺和脾的能力与该生物在体外培养物中存活并在37℃下繁殖的能力有关。在堪萨斯分枝杆菌和海藻分枝杆菌感染的小鼠中产生的足垫肿胀量取决于生物体的菌株和原始足垫接种物的大小而变化。将死死的海藻分枝杆菌注射到脚垫中还引起大量的肿胀，该肿胀随所使用的菌株而变化，并且是剂量依赖性的。接种了海藻支原体和卡介苗的小鼠受到了海藻支原体或高毒力结核分枝杆菌菌株ERDMAN的保护，可以抵御后来的脚垫攻击。关于在脚垫感染模型中使用多种分枝杆菌的交叉保护研究，讨论了这一发现的意义。

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