摘要：Objectives：Human gut flora is a complex microbial ecosystem that plays a major role in human health．Under normal conditions，the gut microflora exists in a state of equilibrium with the host that is mutually beneficial to the degree that it has been described as a separate“organ”adapted to human physiology．Therefore，keeping the equilibrium of the intestinal flora is one of many important factors affecting human health．Liver injury often causes disruption of the gut microflora through the gut-liver axis，altered bile secretion and impaired peristaisis．The work addressed two primary issues regarding the relationship between gut microflora and hepatic damage：first，whether or not changes in gut microflora exacerbated liver damage in a rat model of acute liver injury induced by D-galactosamine (GalN) and，second，defining the possible mechanism(s)involved、To achieve this aim,we induced changes in gut microflora through oral supplementation using several different strains of nonpathogenic E coli，S.enteritidis，probiotics or Gentamicin、Alterations of the intestinal microflora,mucosa，as well as bacterial translocation (BT)，the production of plasma endotoxin levels，and serum IL-10，IL-6，TNF-a,and IL-12concentrations were examined、CD3+T cells and CD4+T cells in peripheral blood and Peyer’s patches in rats were also evaluated．
