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首页> 外文期刊>Infection and immunity >Extension of the mean time to death of mice with a lethal infection of Venezuelan equine encephalomyelitis virus by antithymocyte serum treatment.
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Extension of the mean time to death of mice with a lethal infection of Venezuelan equine encephalomyelitis virus by antithymocyte serum treatment.

机译：通过抗胸腺细胞血清治疗延长了致命感染委内瑞拉马脑脊髓炎病毒的小鼠的平均死亡时间。

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摘要

The mean time to death of mice infected with Venezuelan equine encephalomyelitis (VEE) virus was increased 2 days by antithymocyte serum (ATS) treatment given 1 day before and 1 day after virus inoculation. Virus assays of blood, brain, and spleen indicated that VEE virus replication was delayed by ATS. Additionally, mice treated with ATS exhibited neurological signs later than untreated mice. During the infection, the percentage of splenic B lymphocytes as determined by surface immunoglobulin staining increased. ATS treatment caused a further elevation of the percentage of splenic B lymphocytes. These results show a selective depletion of the non-immunoglobulin-bearing lymphocyte population during VEE virus infection and support the hypothesis that ATS destroys or alters an important population of cells associated with the normal course of pathogenesis and the replication of VEE virus to high titers in the mouse.
机译：接种疫苗前1天和接种后1天给予抗胸腺细胞血清（ATS）处理，可使感染委内瑞拉马脑脊髓炎（VEE）病毒的小鼠的平均死亡时间延长2天。对血液，大脑和脾脏进行的病毒分析表明，ATS延迟了VEE病毒的复制。另外，用ATS治疗的小鼠比未治疗的小鼠更晚表现出神经系统症状。在感染期间，通过表面免疫球蛋白染色确定的脾脏B淋巴细胞的百分比增加。 ATS治疗导致脾脏B淋巴细胞百分比进一步升高。这些结果表明，在VEE病毒感染期间非携带免疫球蛋白的淋巴细胞群的选择性耗竭，并支持ATS破坏或改变与正常发病过程相关的重要细胞群以及VEE病毒向高滴度复制的假说。鼠标。

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