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Effect of vitamin A on the systemic and local antibody responses to intragastrically administered bovine serum albumin.

机译:维生素A对胃内给药牛血清白蛋白的全身和局部抗体反应的影响。

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The effects of vitamin A on the immune response to bovine serum albumin (BSA) were studied in adult mice. Treatment with vitamin A by the intragastric or parenteral routes markedly increased the local as well as the systemic antibody response to different concentrations of the antigen (BSA). In contrast, in animals given BSA alone, antigen concentrations above a certain dose resulted in a decreased or even absent anti-BSA response. These studies suggest that vitamin A may be an appropriate adjuvant in oral immunization.
机译:在成年小鼠中研究了维生素A对牛血清白蛋白(BSA)免疫反应的影响。通过胃内或肠胃外途径用维生素A治疗显着增加了对不同浓度抗原(BSA)的局部和全身抗体反应。相反,在仅给予BSA的动物中,高于一定剂量的抗原浓度会导致抗-BSA反应降低或什至不存在。这些研究表明,维生素A可能是口服免疫的合适佐剂。

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