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Sensitization of Complement-Resistant Smooth Gram-Negative Bacterial Strains

机译：补体抗性光滑革兰氏阴性菌的敏化

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Many gram-negative bacteria are susceptible to the bactericidal action of complement in the presence of specific antibody. As a general rule, rough strains are readily killed, whereas smooth strains are relatively resistant. The results of this study show that the serum sensitivity of smooth gram-negative organisms can be controlled by the environmental conditions imposed by the test system. Smooth organisms which are completely resistant to the bactericidal action of immune serum plus complement in the presence of divalent cations become quite sensitive in a test system containing a relatively high concentration of certain univalent cations; this effect is potentiated by ethylenediaminetetraacetic acid. Since it is generally accepted that the serum resistance of smooth gram-negative organisms is associated with the protection afforded by their thick lipopolysaccharide layer, it is suggested that environmental conditions favoring serum sensitization cause some structural disorganization of the smooth lipopolysaccharide of these cells.
机译：在特异性抗体的存在下，许多革兰氏阴性细菌对补体的杀菌作用敏感。通常，粗菌株容易被杀死，而平滑菌株则相对抗性。这项研究的结果表明，光滑革兰氏阴性生物的血清敏感性可以通过测试系统施加的环境条件来控制。在二价阳离子存在的情况下，对免疫血清加补体的杀菌作用具有完全抵抗力的光滑生物，在含有相对较高浓度的某些单价阳离子的测试系统中变得非常敏感。乙二胺四乙酸增强了这种效果。由于通常认为光滑革兰氏阴性生物的血清抗性与其厚脂多糖层所提供的保护有关，因此建议有利于血清敏化的环境条件会导致这些细胞的光滑脂多糖的某些结构紊乱。

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