Replication of Rabies Virus in Organized Cultures of Mammalian Neural Tissues

Seiichi Matsumoto; Takeshi Yonezawa

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Replication of Rabies Virus in Organized Cultures of Mammalian Neural Tissues

机译：狂犬病病毒在哺乳动物神经组织的有组织培养中的复制

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Organized cultures of dorsal root ganglion and spinal cord ganglion from rat and mouse were used as a model to study the pathogenesis of rabies infection in neural tissue. Two strains of fixed virus and one of street virus were used. Virus replication was similar to that detected in other rabies virus host cell systems, although virus yields remained in relatively low titer. Sequential observations of individual neurons in organized cultures revealed that cytopathic effects usually became evident at 3 days and progressed from cytoplasmic granulation to complete neuronolysis. It was shown by electron microscopy that a small percentage of the inclusion bodies, which appeared in the neurons as well as glial cells, were associated with virus assembly. These findings were similar, regardless of strain of virus employed. Previous experiments done in vivo have shown differences in the type of cytopathic effect produced by street virus and by fixed virus. It is thought that the combination of host cell system and strain of virus is important in determining the course of infection.

机译：用大鼠和小鼠的背根神经节和脊髓神经节的组织培养作为模型来研究神经组织中狂犬病感染的发病机理。使用了两种固定病毒株和一种街头病毒。病毒复制与其他狂犬病病毒宿主细胞系统中检测到的相似，尽管病毒产量仍保持较低滴度。对有组织的培养物中单个神经元的顺序观察表明，细胞病变作用通常在3天后变得明显，并从细胞质颗粒化发展为完全神经溶解。电子显微镜显示，出现在神经元和神经胶质细胞中的小部分包涵体与病毒装配有关。无论使用何种病毒，这些发现都是相似的。先前在体内进行的实验表明，街头病毒和固定病毒产生的细胞病变作用类型有所不同。据认为，宿主细胞系统和病毒株的组合对于确定感染过程很重要。

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《Infection and immunity》 |1971年第4期|共11页
作者
Seiichi Matsumoto; Takeshi Yonezawa;
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1. Further Studies on the Replication of Rabies and Rabies-Like Viruses in Organized Cultures of Mammalian Neural Tissues [J] . S. Matsumoto, L. G. Schneider, A. Kawai, Journal of Virology . 1974,第4期

机译：进一步研究哺乳动物神经组织有组织培养中狂犬病和狂犬病病毒的复制
2. Further Studies on the Replication of Rabies and Rabies-Like Viruses in Organized Cultures of Mammalian Neural Tissues [J] . S. Matsumoto, L. G. Schneider, A. Kawai, Journal of Virology . 1974,第4期

机译：进一步研究哺乳动物神经组织有组织培养中狂犬病和狂犬病病毒的复制
3. Further Studies on the Replication of Rabies and Rabies-Like Viruses in Organized Cultures of Mammalian Neural Tissues [J] . S. Matsumoto, L. G. Schneider, A. Kawai, Journal of Virology . 1974,第4期

机译：进一步研究哺乳动物神经组织有组织培养中狂犬病和狂犬病病毒的复制
4. On-Line Monitoring of Vero Cells Cultures During the Growth and Rabies Virus Process Using Biomass Spectrometer [C] . Samia Rourou, Stephanie Gaumon, and Hela Kallel European Society of Animal Cell Technology . 2010

机译：生物质光谱仪生长和狂犬病病毒过程中VERO细胞培养的在线监测
5. Replication of neurovirulent and non-neurovirulent human H1N1 influenza A viruses in mouse brain and nerve cell cultures: Virus strain-specific and host cell-dependent variations in progeny virus assembly,mRNA splicing efficiency, and expression of RNA gene segments 7 and 8 [D] . Husak, Paul James 1994

机译：在鼠脑和神经细胞培养物中复制神经毒力和非神经毒力的人类甲型H1N1流感病毒：子代病毒装配，mRNA剪接效率以及RNA基因片段7和8的表达中病毒株特异性和宿主细胞依赖性变异
6. Further Studies on the Replication of Rabies and Rabies-Like Viruses in Organized Cultures of Mammalian Neural Tissues [O] . S. Matsumoto, L. G. Schneider, A. Kawai, 1974

机译：进一步研究哺乳动物神经组织组织培养中狂犬病和类似狂犬病病毒的复制
7. Further Studies on the Replication of Rabies and Rabies-Like Viruses in Organized Cultures of Mammalian Neural Tissues [O] . S. Matsumoto, L. G. Schneider, A. Kawai, 1974

机译：进一步研究哺乳动物神经组织有组织培养中狂犬病和狂犬病病毒的复制

Replication of Rabies Virus in Organized Cultures of Mammalian Neural Tissues

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