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首页> 外文期刊>Infection and immunity >Effect of Separate and Combined Injections of Poly rI: Poly rC and Endotoxin on Reticulo-endothelial Activity, Interferon, and Antibody Production in the Mouse
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Effect of Separate and Combined Injections of Poly rI: Poly rC and Endotoxin on Reticulo-endothelial Activity, Interferon, and Antibody Production in the Mouse

机译：单独和联合注射Poly rI：Poly rC和内毒素对小鼠网状内皮活性，干扰素和抗体产生的影响

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The effect of repeated stimulation on both the interferon and antibody systems and on reticuloendothelial activity was studied by injection of endotoxin 2 days before injection of (poly rI):(poly rC). A single injection of endotoxin or (poly rI):(poly rC) increased or decreased the response in each system depending on the time of administration. If the injection of (poly rI):(poly rC) was preceded by an injection of endotoxin 2 days before, its activity was markedly reduced in all of the three systems studied. Although different doses of endotoxin were required to induce a state of hyporeactivity or tolerance to the effects of (poly rI):(poly rC) in either system, it is possible that a common mechanism underlies the hyporeactivity in all systems.
机译：在注射（poly rI）:( poly rC）前2天注射内毒素，研究了重复刺激对干扰素和抗体系统以及网状内皮活性的影响。单次注射内毒素或（poly rI）:( poly rC）会根据给药时间增加或减少每个系统的反应。如果在2天前注射（poly rI）:( poly rC），则在研究的所有三个系统中其活性均明显降低。尽管在任何一个系统中都需要不同剂量的内毒素来诱导反应性低下或对（poly rI）:( poly rC）的作用具有耐受性，但可能有一个共同的机制在所有系统中都具有低反应性。

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