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首页> 外文期刊>Infection and immunity >Cycloserine Induction, Propagation, and Antimicrobial Susceptibility of Wall-Defective Staphylococcus aureus
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Cycloserine Induction, Propagation, and Antimicrobial Susceptibility of Wall-Defective Staphylococcus aureus

机译：壁缺陷性金黄色葡萄球菌的环丝氨酸的诱导，繁殖和抗药性

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摘要

A method of induction of L colonies of Staphylococcus aureus by cycloserine, the propagation of wall-defective staphylococci (WDS), and the development and antimicrobial susceptibility of stable WDS are presented. The growth and morphology of the cycloserine-induced L colonies and WDS were indistinguishable from those induced by methicillin or lysostaphin. The antimicrobial susceptibility of the stable cycloserine-induced WDS was similar to that of the stable methicillin-induced and lysostaphin-induced WDS by both broth dilution and agar diffusion techniques. A survey of the English literature reveals that wall-defective bacteria are always resistent to antimicrobial agents which inhibit cell wall synthesis (cycloserine, penicillins, and cephalosporins). They are virtually all susceptible to antimicrobial agents which have other modes of action. The susceptibility to vancomycin and bacitracin varied from study to study.
机译：提出了一种利用环丝氨酸诱导金黄色葡萄球菌L菌落的方法，壁缺陷性葡萄球菌的繁殖，稳定WDS的发展及其对抗生素的敏感性。环丝氨酸诱导的L菌落和WDS的生长和形态与甲氧西林或溶葡萄球菌素诱导的菌落没有区别。通过肉汤稀释和琼脂扩散技术，稳定的环丝氨酸诱导的WDS的抗菌敏感性与稳定的甲氧西林诱导的和溶葡萄球菌素诱导的WDS相似。对英国文献的调查表明，壁缺陷细菌始终对抑制细胞壁合成的抗菌剂（环丝氨酸，青霉素和头孢菌素）具有抵抗力。它们实际上都易受具有其他作用方式的抗菌剂的侵害。不同研究对万古霉素和杆菌肽的敏感性不同。

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