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Australia Antigen: Persistence of Immunological Markers (d, y, w) in Antigen Carriers

机译:澳大利亚抗原:抗原载体中的免疫标记物(d,y,w)持续存在

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It is important to establish the stability of Australia antigen subtypes in chronic carriers in order to evaluate the validity of using immunological determinants as long-term epidemiological markers. In this study sequential blood samples containing Australia antigen from 31 chronic carriers were typed for determinants d, y, and w. The subjects included asymptomatic carriers from Rongelap Atoll in the Marshall Islands, Down's syndrome patients, and renal patients receiving hemodialysis treatment. The period of time between blood samples extended from 3 months to 11 years. In no case did the subtype change within any individual. It appears from these data that the Australia antigen subtypes are good long-term markers for epidemiological studies.
机译:建立澳大利亚抗原亚型在慢性携带者中的稳定性对于评估使用免疫学决定子作为长期流行病学标记的有效性非常重要。在这项研究中,对来自31个慢性携带者的包含澳大利亚抗原的连续血液样本进行分类,以确定其d,y和w。受试者包括来自马绍尔群岛Rongelap环礁的无症状携带者,唐氏综合症患者和接受血液透析治疗的肾脏患者。两次血液采样之间的时间从3个月延长至11年。在任何情况下,亚型都不会在任何个体内发生变化。从这些数据看来,澳大利亚抗原亚型是流行病学研究的良好长期标记。

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