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Correlation between phagocytic activity and metabolic response of polymorphonuclear leukocytes toward different strains of Escherichia coli.

机译:吞噬活性与多形核白细胞对不同菌株的代谢反应之间的相关性。

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The bactericidal activity, the phagocytic capacity, and the metabolic stimulation of polymorphonuclear leukocytes challenged with different strains of Escherichia coli were studied. It was found that only two strains out of 10 tested stimulated the oxygen consumption and carbohydrate metabolism of leukocytes and were readily killed by the phagocytes. The lack of killing of the other eight strains was shown to be due to absent or poor phagocytosis rather than to resistance to intracellular killing. Evidence was presented that the surface K antigen plays an important role in conferring antiphagocytic properties to some strains of E. coli. It was suggested that K antigen acts by interfering with the early step of the phagocytic process, that is, the attachment step.
机译:研究了用不同菌株攻击的多形核白细胞的杀菌活性,吞噬能力和代谢刺激。发现在测试的十个菌株中只有两个菌株刺激白细胞的耗氧量和碳水化合物代谢,并且很容易被吞噬细胞杀死。显示出对其他八种菌株缺乏杀伤力是由于缺乏吞噬作用或吞噬能力差而不是由于对细胞内杀伤力的抵抗力。已有证据表明表面K抗原在赋予某些大肠杆菌抗吞噬特性中起重要作用。提示K抗原通过干扰吞噬过程的早期步骤,即附着步骤而起作用。

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