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首页> 外文期刊>Infection and immunity >Association of viable and inactivated Salmonella typhimurium 395 MS and MR 10 with HeLa cells.
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Association of viable and inactivated Salmonella typhimurium 395 MS and MR 10 with HeLa cells.

机译：活的和灭活的鼠伤寒沙门氏菌395 MS和MR 10与HeLa细胞的关联。

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摘要

The mouse-virulent Salmonella typhimurium 395 MS, containing a complete lipopolysaccharide (LPS) structure with S-specific repeating units, and the nonvirulent, LPS-defective mutant 395 MR 10 (chemotype Rd), derived from it, were studied for their tendency to interact with HeLa cells. In the definition of interaction no distinction has been made between intracellular and cell membrane-attached bacteria. R10 bacteria were found to have a greater tendency to interact than MS bacteria. This difference was seen as early as 1 h after the start of incubation, but it became more pronounced beyond 3 h. Heat-killed and ultraviolet-killed R10 bacteria interacted with HeLa cells less than living ones. Killed MS bacteria interacted to an extent similar to that of living ones. These results are discussed in relation to the susceptibility of the bacteria to phagocytosis by professional phagocytic cells and to the physiochemical properties of the bacteria as measured by their distribution in a two-polymer, aqueous-phase system.
机译：研究了鼠毒性鼠伤寒沙门氏菌395 MS（包含具有S特异性重复单元的完整脂多糖（LPS）结构）和衍生自其的无毒，LPS缺陷型突变体395 MR 10（化学型Rd）的趋势。与HeLa细胞相互作用。在相互作用的定义中，在细胞内和细胞膜上附着的细菌之间没有区别。发现R10细菌比MS细菌具有更大的相互作用趋势。这种差异最早可在孵育开始后1小时看到，但在3小时后变得更加明显。热灭活和紫外线灭活的R10细菌与HeLa细胞的相互作用比活菌少。被杀死的MS细菌的相互作用程度类似于活菌。讨论了这些结果，涉及细菌对专业吞噬细胞吞噬作用的敏感性以及通过细菌在两元聚合物水相系统中的分布测量的细菌的理化性质。

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