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首页> 外文期刊>Infection and immunity >Aerosol vaccination of mice with a live, temperature- sensitive recombinant influenza virus.
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Aerosol vaccination of mice with a live, temperature- sensitive recombinant influenza virus.

机译：用对温度敏感的活重组流感病毒对小鼠进行气雾接种。

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Mice were vaccinated intranasally (i.n.) or with small-particle aerosols (SPA; 2 mum) or large-particle aerosols (LPA; 8 mum) of an attenuated, temperature-sensitive, recombinant A influenza (H3N2) virus, ts-1 (E). Serum virus-neutralizing and hemagglutination inhibition antibodies were detected for all vaccinated mice by 28 days. Bronchoalveolar wash fluids had increased levels of immunoglobulin (IgG, IgA) only in the i.n. -vaccinated mice. Hemagglutination and virus-neutralizing antibodies were detected in the SPA- and i.n. -vaccinated groups but not in the LPA vaccinates. Upon challenge with SPA of a mouse virulent H3N2 influenza vitus, total protection was obtained for the SPA- and I.N. -vaccinated mice, whereas only 89% of the LPA group survived. Replication of the challenge virus was signifcantly repressed in both the lower and upper respiratory tracts of the three groups of vaccinated mice compared to the nonvaccinated controls. The protection afforded the SPA- and i.n. -vaccinated mice was the same as measured for mice after recovery from earlier subelthal active infection with virulent virus.
机译：对小鼠鼻内（in）或用减毒的对温度敏感的重组A型流感（H3N2）病毒ts-1（）的小颗粒气雾剂（SPA; 2 mum）或大颗粒气雾剂（LPA; 8 mum）进行疫苗接种。 E）。到28天，所有接种疫苗的小鼠都检测到血清病毒中和和血凝抑制抗体。支气管肺泡洗液仅在输卵管中具有较高的免疫球蛋白（IgG，IgA）水平。疫苗接种的小鼠。在SPA和i.n中检测到血凝和病毒中和抗体。疫苗接种组，但LPA疫苗接种组除外。用小鼠毒性H3N2流感病毒的SPA攻击后，获得了对SPA-和I.N.的全面保护。疫苗接种的小鼠，而LPA组中只有89％存活。与未接种疫苗的对照组相比，接种疫苗的三组小鼠的下呼吸道和上呼吸道均显着抑制了挑战病毒的复制。该保护提供了SPA-和i.n.疫苗接种的小鼠与从较早的有毒病毒的皮下活动性感染恢复后的小鼠相同。

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