Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients.

R U Sorensen; R C Stern; S H Polmar

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Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients.

机译：细胞对细菌的免疫力：囊性纤维化患者体外对铜绿假单胞菌的淋巴细胞反应受损。

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Lymphocyte responses to the mitogens phytohemagglutinin and concanavalin A and to Streptococcus pyogenes, Staphylococcus aureus, Haemophilus influenzae, and Pseudomonas aeruginosa were evaluated in patients with cystic fibrosis and in normal individuals. Lymphocyte proliferation in vitro was stimulated by gentamicin-killed whole bacteria, and the proliferative response was measured by [3H]thymidine incorporation. The in vitro lymphocyte responses to antibiotic-killed bacterial reached maximum thymidine incorporation after 5 days in culture and followed a unimodal dose-response curve for each of the bacteria studied. A significant specific incapacity to respond to P. aeruginosa was detected in cystic fibrosis patients with advanced clinical disease.

机译：在患有囊性纤维化的患者和正常个体中，评估了淋巴细胞对促细胞分裂素植物凝集素和伴刀豆球蛋白A以及化脓性链球菌，金黄色葡萄球菌，流感嗜血杆菌和铜绿假单胞菌的反应。庆大霉素杀死的完整细菌刺激体外淋巴细胞增殖，并通过[3H]胸苷掺入来测量增殖反应。培养5天后，对抗生素杀死的细菌的体外淋巴细胞反应达到最大的胸腺嘧啶核苷掺入量，并遵循每种研究细菌的单峰剂量反应曲线。在患有晚期临床疾病的囊性纤维化患者中检测到对铜绿假单胞菌有明显的特异性丧失治疗能力。

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《Infection and immunity》 |1977年第3期|共6页
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R U Sorensen; R C Stern; S H Polmar;
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中图分类医学免疫学;
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1. In vitro activity of doripenem against Pseudomonas aeruginosa and Burkholderia cepacia isolates from both cystic fibrosis and non-cystic fibrosis patients. [J] . Traczewski MM, Brown SD Antimicrobial agents and chemotherapy. . 2006,第2期

机译：多瑞培南对铜绿假单胞菌和洋葱伯克霍尔德菌分离株的体外活性来自囊性纤维化和非囊性纤维化患者。
2. Influence of Cystic Fibrosis Plasma on Lymphocyte Responses to Pseudomonas Aeruginosa In Vitro [J] . Ricardo U Sorensen, Patricia A Chase, Robert C Stern, Pediatric Research . 1981,第1期

机译：囊性纤维化血浆对铜绿假单胞菌淋巴细胞反应的影响
3. Antibody response against Pseudomonas aeruginosa Pseudomonas aeruginosa and its relationship with immune mediators in the upper and lower airways of cystic fibrosis patients [J] . Mauch Renan M., Hentschel Julia, Aanaes Kasper, Pediatric Pulmonology . 2020,第4期

机译：针对假单胞菌铜绿假单胞菌铜绿假单胞菌的抗体反应及其与囊性纤维化患者的上下航向和下渠道中免疫介质的关系
4. MEMBRANE PROTEOME CHARACTERIZATION OF PHENOTYPICALLY DIVERSE PSEUDOMONAS AERUGINOSA CYSTIC FIBROSIS ISOLATES REVEALS ADAPTATION TO HOST LUNGS [C] . Karthik Shantharam Kamath, Dana Pascovici, Apurv Goel, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：表型多样性铜绿假单胞菌孢子素囊性纤维化分离物的膜蛋白质组特征揭示了对宿主肺的适应
5. Mechanisms of DNA repair and damage tolerance in Pseudomonas aeruginosa: Implications for cystic fibrosis patients. [D] . Sanders, Laurie Heather. 2008

机译：铜绿假单胞菌的DNA修复和损伤耐受机制：对囊性纤维化患者的影响。
6. Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients. [O] . R U Sorensen, R C Stern, S H Polmar 1977

机译：细胞对细菌的免疫力：囊性纤维化患者体外对铜绿假单胞菌的淋巴细胞反应受损。
7. Cough-generated aerosols of Pseudomonas aeruginosa and other Gram Negative Bacteria from cystic fibrosis patients. [O] . Wainwright Claire, France Megan, ORouke Peter, 2009

机译：由囊性纤维化患者咳嗽产生的铜绿假单胞菌和其他革兰氏阴性细菌气溶胶。
8. Relation between Antibody Response to Pseudomonas aeruginosa Exoproteins and Colonization/Infection in Patients with Cystic Fibrosis [R] . Granstrom, M., Ericsson, B., Strandvik, B., 1984

机译：囊性纤维化患者铜绿假单胞菌前体蛋白抗体应答与定植/感染的关系

Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients.

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