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首页> 外文期刊>Infection and immunity >Measles virus-specific antibodies and immunoglobulin M antiglobulin in sera from multiple sclerosis and rheumatoid arthritis patients.
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Measles virus-specific antibodies and immunoglobulin M antiglobulin in sera from multiple sclerosis and rheumatoid arthritis patients.

机译：多发性硬化症和类风湿关节炎患者血清中的麻疹病毒特异性抗体和免疫球蛋白M抗球蛋白。

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摘要

When rheumatoid factor in rheumatoid arthritis and multiple sclerosis sera was titrated by the fluorescent antibody method on measles virus-infected cells, there was a marked and variable drop in titer on acetone-fixed cells as compared with unfixed cells. This was accounted for by the failure of measles virus hemolysin-inhibiting (HLI) antibody of the immunoglobulin G class to bind to acetone-fixed infected cells. It was shown by staining unfixed and acetone-fixed measles virus-infected cells that rheumatoid factor in most rheumatoid arthritis sera combined with measles virus-specific hemagglutinin-inhibiting and HLI antibodies, whereas rheumatoid factor in multiple sclerosis sera combined only with HLI antibody. Rheumatoid factor of similar specificity was also observed in normal sera and occasionally in rheumatoid arthritis sera. Both rheumatoid arthritis and multiple sclerosis sera showed almost identical increases in average titer above normal of measles virus-specific fluorescent staining immunoglobulin G and HLI antibodies.
机译：当通过荧光抗体法对麻疹病毒感染的细胞中的类风湿关节炎和多发性硬化症血清中的类风湿因子进行滴定时，与未固定的细胞相比，丙酮固定的细胞的滴度显着且可变。这是由于免疫球蛋白G类的麻疹病毒溶血素抑制（HLI）抗体无法与丙酮固定的感染细胞结合而造成的。通过对未固定和丙酮固定的麻疹病毒感染的细胞进行染色显示，大多数类风湿性关节炎血清中的类风湿因子与麻疹病毒特异性血凝素抑制抗体和HLI抗体结合，而多发性硬化血清中的类风湿因子仅与HLI抗体结合。在正常血清中也观察到相似特异性的类风湿因子，偶尔在类风湿关节炎血清中也观察到。类风湿关节炎和多发性硬化症血清均显示出比正常水平的麻疹病毒特异性荧光染色免疫球蛋白G和HLI抗体平均滴度几乎相同的增加。

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