• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Pathogenesis of Tularemia in Monkeys Aerogenically Exposed to Francisella tularensis 425
【24h】

Pathogenesis of Tularemia in Monkeys Aerogenically Exposed to Francisella tularensis 425

机译：土拉弗朗西斯菌425暴露于猴子的Tularemia发病机理

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The pathogenesis of tularemia was studied in groups of rhesus monkeys (Macaca mulatta) that inhaled graded 10-fold doses ranging from 10 through 106 organisms of Francisella tularensis 425, a strain highly virulent for the white mouse but of reduced virulence for the domestic rabbit. Mean incubation periods ranged from 3 to 6 days followed by acute illness lasting 5 to 11 days with subsequent recovery of most animals. The higher inhaled doses resulted in shorter incubation periods, longer and more severe acute illnesses, and 18% mortality at the highest dose. Strain 425 multiplied in the lungs, disseminated to the regional lymph nodes, and became systemic. Maximal bacterial populations in tissues were reached by the 7th day after exposure of the animals regardless of the number of organisms inhaled. F. tularensis was no longer recoverable from any of six tissues examined 2 months after exposure. The most significant tissue changes occurred in the lungs; these consisted of foci of liquefaction necrosis, lobular consolidation, and pleural effusion and adhesions. The data indicate that the inhaled dose of strain 425 determined the maximal growth of the organism in the lungs which in turn influenced the severity of the usually self-limiting pneumonia and systemic infection. Although the monkey is less resistant to tularemia than is man, this laboratory animal when infected with F. tularensis 425 provides a useful model for the self-limiting type of human pulmonary tularemia usually observed in Europe and Asia but to a lesser extent in North America.
机译：研究了恒河猴（猕猴）吸入10到10 6 种等级的10倍剂量的恒河猴（ Francisella tularensis < / em> 425，一种对白色小鼠有高毒力但对家兔的毒力却降低的毒株。平均潜伏期为3至6天，随后为急性疾病，持续5至11天，大多数动物随后康复。较高的吸入剂量会导致潜伏期缩短，急性疾病发作时间更长，更严重，在最高剂量下的死亡率为18％。 425菌株在肺中繁殖，扩散到区域淋巴结，并成为全身性的。不论动物吸入多少种细菌，在接触动物后第7天都可以达到组织中的最大细菌种群。 F。暴露2个月后检查的6个组织中的任何一个组织都无法再恢复tularensis 。最显着的组织变化发生在肺部。这些包括液化坏死灶，小叶巩固灶，胸腔积液和粘连灶。数据表明菌株425的吸入剂量决定了微生物在肺中的最大生长，进而影响了通常自限性肺炎和全身感染的严重程度。尽管猴子对图拉虫病的抵抗力不及人类，但该实验室动物感染 F时。 tularensis 425提供了一种有用的模型，用于通常在欧洲和亚洲观察到的自限型人类肺部tularemia，但在北美却较少。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号