Enterobacter cloacae strain SS4-56 produced salmonellosis pacifarins when grown in an iron-depleted synthetic medium to which 3.16 X 10-7 g-atom of iron had been added per liter, but did not do so when grown in iron-depleted medium supplemented with 3.16 X 10-4 g-atom of iron per liter. The addition of 3.16 X 10-4 g-atom of ferric iron per liter to a pacifarin-containing culture supernatant fluid had no significant effect upon the ability of the active pacifarins present, when administered per os, to protect mice from an otherwise fatal infection produced by a sequential injection of avirulent and virulent strains of Salmonella typhimurium.
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机译:阴沟肠杆菌菌株SS4-56在贫铁合成培养基中生长时会产生沙门氏菌帕西法林,每升中已添加3.16 X 10-7 g原子的铁,但在补充有铁的贫铁培养基中生长时却没有每升铁3.16 X 10-4克原子铁。每升含帕西法林的培养上清液中每升添加3.16 X 10-4 g原子的三价铁原子,对经口服给予的活性帕西法林保护小鼠免受致命性感染的能力没有明显影响。通过依次注射鼠伤寒沙门氏菌的无毒力和强毒力产生。
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