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Adsorption of Typhus Rickettsiae to Ghosts of Sheep Erythrocytes

机译：斑疹伤寒立克次体对绵羊红细胞鬼魂的吸附

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Rickettsia prowazeki will adsorb to ghosts derived from sheep erythrocytes by hypotonic lysis. Adsorption to ghosts, as to intact erythrocytes, is dependent on the metabolism of the rickettsiae. KCN and 0 C inhibit adsorption. Fluoride, while inhibiting hemolysis, has no effect on adsorption to ghosts or intact erythrocytes. The adsorption of rickettsiae to ghosts does not lead to lysis, in that fluorescent albumin can be retained by the ghost after adsorption. Both inside-out and right-side-out vesicles formed from the ghost are equally capable of adsorption, indicating that the receptor is stable during the process of vesiculation and is not localized to one aspect of the cell membrane. Adsorption to ghosts is slower and displays less affinity than to the intact erythrocyte. The ghost system will be useful in characterizing the membrane receptor for rickettsia and in establishing assays for adsorption to other cells.
机译： Rickettsia prowazeki 将通过低渗裂解吸附到来自绵羊红细胞的幽灵上。至于完整的红细胞，对鬼的吸附取决于立克次体的代谢。 KCN和0 C抑制吸附。氟化物在抑制溶血的同时，对重影或完整红细胞的吸附没有影响。立克次体对鬼影的吸附不会导致溶解，因为荧光白蛋白在吸附后可以被鬼影保留。由重影形成的由内向外和从右侧向外的囊泡均具有相同的吸附能力，这表明受体在囊泡形成过程中是稳定的，并且不局限于细胞膜的一个方面。与完整的红细胞相比，对重影的吸附较慢并且显示出较小的亲和力。幻影系统可用于表征立克次体的膜受体，并用于建立吸附至其他细胞的测定方法。

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