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首页> 外文期刊>Infection and immunity >Environmental modification of western equine encephalomyelitis infection in the snowshoe hare (Lepus americanus).
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Environmental modification of western equine encephalomyelitis infection in the snowshoe hare (Lepus americanus).

机译：环境修饰雪兔（西部美洲兔）中的西部马脑脊髓炎感染。

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The snowshoe hare (Lepus americanus) could be infected with western equine encephalomyelitis (WEE) virus and produce a viremia. Furthermore, viremia in hares exposed to variable climatic conditions differed significantly from viremias seen in the control animals held at constant temperatures. The viremia duration and titer were increased in animals subjected to fluctuating temperature and humidity. The time of onset of viremia was accelerated. Antibody response also increased in animals exposed to varying temperatures when compared with controls held at constant temperature and humidity. Snowshoe hares were studied at two distinct seasonal periods: winter, before reproductive activity; and summer, during reproductive midseason. Winter animals experienced greater viremia than did summer hares when exposed to fluctuating temperatures, suggesting a seasonality in the hare's susceptibility to host modification by environmental influences. These findings implicate the snowshoe hare as a possible mammalian amplifying host for WEE virus in the boreal forest.
机译：雪兔（Lepus americanus）可能感染西部马脑脊髓炎（WEE）病毒并产生病毒血症。此外，暴露于不同气候条件的野兔中的病毒血症与恒温条件下的对照动物的病毒血症有显着差异。在波动的温度和湿度下，动物的病毒血症持续时间和滴度增加。病毒血症的发作时间加快了。与保持在恒定温度和湿度下的对照相比，暴露于不同温度的动物的抗体反应也增加。在两个不同的季节研究了雪鞋野兔：冬天，生殖活动之前;和夏天，生殖中期。当暴露于温度波动时，冬季动物的病毒血症要比夏季野兔大，这表明野兔易受环境影响而发生宿主变态的季节性。这些发现暗示雪鞋野兔可能是北方森林中WEE病毒的哺乳动物放大宿主。

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