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首页> 外文期刊>Infection and immunity >Establishment of a nonproductive herpes simplex virus infection in rabbit kidney cells.
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Establishment of a nonproductive herpes simplex virus infection in rabbit kidney cells.

机译：在兔肾细胞中建立非生产性单纯疱疹病毒感染。

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A nonproductive infection of rabbit kidney cells was established with a type 2 strain of herpes simplex virus after incubation of the virus-infected cells at 41 C. Although infectious virus could not be recovered from cells disrupted by freeze-thawing or sonication after incubation at 41 C, spontaneous reactivation of virus growth occurred in 84% of the cultures after lag periods of variable length when cultures of viable cells were transferred to 37 C and incubated. Forty-one percent of the cultures had lag periods of 4 or more days, and 24% had lag periods of 7 or more days. The longest lag period was 45 days. A similar infection was established in WI-38 cells, but attempts to establish the infection in human kidney cells was not successful. This nonproductive infection is being used to study the effects of various physical and chemical agents on herpes simplex virus in a latent state.
机译：在41℃下孵育感染了病毒的细胞后，用2型单纯疱疹病毒株建立了兔肾细胞的非生产性感染。尽管在41℃下孵育后无法通过冷冻-解冻或超声处理破坏的细胞中无法恢复感染性病毒C，当将活细胞的培养物转移至37℃并孵育时，在可变长度的滞后后84％的培养物中发生病毒生长的自发性再激活。 41％的培养物的迟滞期为4天或更长时间，而24％的培养物的迟缓期为7天或更长时间。最长的滞后时间是45天。在WI-38细胞中建立了类似的感染，但是在人肾细胞中建立感染的尝试并未成功。这种非生产性感染被用于研究各种物理和化学制剂对潜伏状态的单纯疱疹病毒的影响。

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