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首页> 外文期刊>Infection and immunity >Angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.
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Angiostrongylus cantonensis: phospholipase in nonsensitized and sensitized rats after challenge.

机译：广东血管圆线虫：激发后未致敏和致敏大鼠中的磷脂酶。

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摘要

Rats given an initial infection with Angiostrongylus cantonensis had moderately elevated phospholipase B activity in the lungs at 8 and 15 days after challenge, and greatly elevated levels were evident at 35, 43, and 49 days. In the brain, the values were elevated at 15 through 35 days. These periods of increased activity in the lungs and brain coincided with the migration patterns of the third stage larvae and the adult worms in this host. The elevated enzyme levels also were were correlated with increased numbers of eosinophils in the bone marrow at 8 and 15 days and again at 36, 43, and 49 days after infection. Similarly infected rats exhibited leukocytosis at 1 through 10 weeks of observation after challenge, and striking eosinophilia at 1, 7, 8, and 9 weeks. Rats reinfected after removal of the worms of the initial infection by thiabendazole treatment showed an anamnestic response characterized by (i) elevated enzyme values in both the lungs and brain at 1 day after reinfection and (ii) eosinophilia in the bone marrow by day 4. These accelerated responses were accompanied by a significant reduction in the worm burden of the rats. The results, which support our hypothesis that inflammation, elevated phospholipase B activity, and reduction in worm burden are causally related, are discussed in light of similar findings reported earlier from our studies with Trichinella spiralis and Nippostrongylus brasiliensis.
机译：初次感染广州血管圆线虫的大鼠在攻击后第8和15天肺中的磷脂酶B活性适度升高，并且在35、43和49天时明显升高。在大脑中，该值在15到35天时升高。这些在肺和脑中活动增加的时期与该宿主中第三阶段幼虫和成虫的迁移模式相吻合。感染后第8天和15天，以及再次在36、43和49天，升高的酶水平也与骨髓中嗜酸性粒细胞数量的增加有关。相似的感染大鼠在攻击后1至10周观察到白细胞增多，并在1、7、8和9周出现嗜酸性粒细胞增多。噻苯达唑处理去除初次感染的蠕虫后再感染的大鼠表现出记忆消除反应，其特征是（i）再感染后1天，肺和脑中的酶值升高，以及（ii）到第4天，骨髓中嗜酸性粒细胞增多。这些加速的反应伴随着大鼠蠕虫负担的显着降低。根据我们先前对旋毛虫和巴西夜蛾的研究报告的类似发现，讨论了支持炎症假说，升高的磷脂酶B活性和蠕虫负担减少之间存在因果关系这一假说的结果。

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