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首页> 外文期刊>Infection and immunity >Ultrastructural changes of cultured human amnion cells by Clostridiu difficile toxin.
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Ultrastructural changes of cultured human amnion cells by Clostridiu difficile toxin.

机译：艰难梭菌毒素培养的人羊膜细胞的超微结构变化。

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The ultrastructure of the surface of primary human amnion monolayer cells undergoing cytopathology induced by Clostridium difficile toxin was examined by scanning electron microscopy. Our observations indicated that the type and distribution of cell surface projections were altered dramatically by this toxin. The patterns of such surface changes were specific for the two different types of cells found in this cell culture. Cells with demarcated borders showed rearrangement of microvilli into globular chains or ridges which lined up with the branching membrane. Cells without demarcated borders exhibited studlike microvilli, all arranged into ridges or globular chains. These changes were noted after 1 h of toxin exposure and persisted without further progression, in spite of continued toxin exposure, up to 48 h. These data indicate that C. difficile produces a cytolytic toxin and that scanning electron microscopy may be useful in determining toxin-cell interactions.
机译：通过扫描电子显微镜检查了经历艰难梭菌毒素诱导的细胞病理学的人羊膜单层单层细胞表面的超微结构。我们的观察表明，这种毒素极大地改变了细胞表面突起的类型和分布。这种表面变化的模式对这种细胞培养物中发现的两种不同类型的细胞具有特异性。具有边界的细胞显示微绒毛重排成球状链或脊，与分支膜对齐。没有边界的细胞表现出类似螺柱的微绒毛，全部排列成脊或球状链。这些变化在毒素暴露1 h后被注意到，并且尽管持续不断地暴露毒素，直至48 h仍持续无进一步进展。这些数据表明艰难梭菌产生细胞溶解毒素，并且扫描电子显微镜可能在确定毒素与细胞的相互作用中很有用。

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