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首页> 外国专利> Synthetic sequences of DNA encoding the heavy chain antibodies to IL-6 HUMAN, synthetic DNA sequence encoding a light chain antibodies to IL-6 HUMAN vectors, antibodies to IL-6 and a strain of human cultured cells - producers of humanized antibody against interleukin-6 HUMAN

Synthetic sequences of DNA encoding the heavy chain antibodies to IL-6 HUMAN, synthetic DNA sequence encoding a light chain antibodies to IL-6 HUMAN vectors, antibodies to IL-6 and a strain of human cultured cells - producers of humanized antibody against interleukin-6 HUMAN

机译：编码针对IL-6 HUMAN的重链抗体的DNA的合成序列，编码针对IL-6 HUMAN载体的轻链抗体，针对IL-6的抗体和人类培养细胞株的合成DNA序列-人源化抗白介素抗体的生产者6人

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1. An antibody to the human interleukin-6, comprising a CDR-portions installed Kabat by Seq ID No: 1-6 and having the sequence of the variable region of the heavy chain of Seq ID No 7 and the sequence of the variable region of the light chain of Seq ID No 8.2. The strain of Chinese hamster ovary cell, deposited in the Russian Collection of Cell Cultures under number RKKK (R) 763D-producing humanized antibody against human interleukin-6 according to claim. 1.3. A synthetic DNA sequence encoding the heavy chain of the humanized antibody to the human interleukin-6 according to claim. 2, shown in Seq ID No 9.4. A synthetic DNA sequence encoding the light chain of the humanized antibody to the human interleukin-6 according to claim. 2, shown in Seq ID No 10.5. The vector for expression of humanized antibody heavy chain to the human interleukin-6 in Chinese hamster cells containing the DNA sequence of claim. 3 shown in Seq ID No 9.6. A vector for expression of the light chain of the humanized antibody to human interleukin-6 in Chinese hamster cells comprising a DNA sequence of claim. 4 shown in Seq ID No 10.
机译：1.一种人白介素-6的抗体，其包含由Seq ID No：1-6安装在Kabat上的CDR部分，并具有Seq ID No 7的重链可变区的序列和可变区的序列。 Seq ID No 8.2的轻链。 7.根据权利要求1的中国仓鼠卵巢细胞株，其以产生RKKK（R）763D的人源化人源化抗体保藏在俄罗斯细胞培养物保藏中心。 1.3。 7.合成的DNA序列，其编码根据权利要求1的抗人白介素-6的人源化抗体的重链。 2，如Seq ID 9.4中所示。 7.合成的DNA序列，其编码根据权利要求1的人源化白细胞介素6的人源化抗体的轻链。 2，显示在Seq ID No 10.5中。 24.一种用于在中国仓鼠细胞中表达人白细胞介素6的人源化抗体重链的载体，该载体含有权利要求1的DNA序列。 3在Seq ID No 9.6中显示。 24.一种用于在中国仓鼠细胞中表达针对人白介素-6的人源化抗体的轻链的载体，其包含权利要求1的DNA序列。 Seq ID No 10中显示4。

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