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首页> 外文期刊>Infection and immunity >Experimental infection of rabbit ligated ileal loops with Treponema hyodysenteriae.
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Experimental infection of rabbit ligated ileal loops with Treponema hyodysenteriae.

机译：实验性感染猪痢疾密螺旋体结扎回肠。

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摘要

An in vivo animal model was used to assess the enteropathogenicity of the etiological agent (Treponema hyodysenteriae) of swine dysentery. Multiple ligated ileal loops, prepared in New Zealand white rabbits, were challenged with either pathogenic (B78 and B204) or nonpathogenic (Pu) isolates of the organism. The pathogenic isolates induced the onset of intestinal fluid accumulation as early as 4 h, with maximal fluid induction at 18 h postchallenge. Gross lesions of the intestinal mucosa, observed in ileal loops of rabbits sacrificed 24 h postchallenge, were characteristic of swine dysentery. Both pathogenic isolates colonized the epithelial surface and eroded the mucosal barrier, as determined by histological and scanning electron microscopic observations. Intestinal fluid accumulation and erosion of the mucosal barrier were not observed in ileal loops exposed to the nonpathogenic isolate (Pu) or to either of the nonviable pathogenic (B78 and B204) isolates. The ability of pathogenic isolates to initiate and produce infection in rabbit ligated ileal loops, which closely resembles the disease in swine, provides a system with which to study experimental swine dysentery.
机译：使用体内动物模型评估猪痢疾的病原体（猪痢疾螺旋体）的肠致病性。用该病原体（B78和B204）或非致病性（Pu）分离株攻击在新西兰白兔中制备的多个结扎回肠环。病原菌最早在4 h便引起肠液积聚，在攻击后18 h诱导液量最大。在攻击后24小时处死的兔子的回肠loop中观察到肠粘膜的总损伤是猪痢疾的特征。通过组织学和扫描电子显微镜观察确定，这两种病原菌都定植在上皮表面并侵蚀了粘膜屏障。在暴露于非致病性分离株（Pu）或非致病性分离株（B78和B204）的回肠loop中，未观察到肠液积聚和粘膜屏障侵蚀。病原菌在兔子结扎的回肠ile中引发和产生感染的能力非常类似于猪中的疾病，为研究实验性猪痢疾提供了一个系统。

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