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An Ultrastructural Analysis of Nocardia During Experimental Infections in Mice

机译:小鼠实验感染过程中诺卡氏菌的超微结构分析

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Several strains of Nocardia that varied from virulent to avirulent were injected intraperitoneally into young mice. Histological and ultrastructural analysis of the resultant infections revealed that the bacteria and the lesions they induced were different depending upon the strain of organism used. Further, the morphological and tinctorial characteristics of the bacteria grown in vitro changes during growth in vivo. These observations strongly suggested that chemical and physical alterations occurred in the cell envelope of the Nocardia when grown in mice. Electron microscopy confirmed that significant structural modification occurred, especially in the cell envelope, when the nocardial cells established themselves within the host tissue. It was shown that the least virulent strain exhibited the most dramatic changes whereas the most virulent organism appeared to be affected the least.
机译:将几株从强毒到无毒的诺卡氏菌菌株腹膜内注射到年轻小鼠体内。对最终感染的组织学和超微结构分析表明,细菌和它们引起的损伤取决于所用生物的菌株而不同。此外,体外生长的细菌的形态和着色特性在体内生长期间改变。这些观察结果强烈表明,在小鼠体内生长时,诺卡氏菌的细胞膜发生了化学和物理改变。电子显微镜证实,当心肌细胞在宿主组织内建立自身状态时,尤其是在细胞包膜中发生了明显的结构修饰。结果表明,毒性最低的菌株表现出最大的变化,而毒性最高的生物似乎受到的影响最小。

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