• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Fate of Intravenously Injected Mycoplasma arthridis in Rodents and Effect of Vaccines
【24h】

Fate of Intravenously Injected Mycoplasma arthridis in Rodents and Effect of Vaccines

机译：啮齿动物静脉注射支原体关节炎的命运和疫苗的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Virulent Mycoplasma arthritidis strain 158 P10 was rapidly eliminated from the peripheral circulation of rats and mice during the first 2 h after intravenous injection of the organisms. Characteristically after this time, the numbers of viable organisms remained remarkably constant through 48 to 72 h. The inability to clear the remaining mycoplasmas was not due to reticuloendothelial blockade but appeared to indicate the presence of a certain number of cells which were resistant to the clearance mechanism. Rat blood was usually devoid of mycoplasmas at 6 days and mouse blood was sterile by 14 days. An occasional transient mycoplasmemia occurred after these times. Avirulent M. arthritidis strain H606 was cleared more rapidly from rats in which it is non-arthritogenic. Different, but characteristic, clearance curves were obtained in mice using M. hominis, M. bovirhinis, and M. pulmonis. Active immunization procedures resulted in enhanced clearance of virulent M. arthritidis from rats. These procedures were less successful in mice. The results of passive immunization of normal rats and mice using convalescent serum indicated the presence of a serum factor which greatly enhanced clearance from rats but had only minimal effects in mice. This serum factor could not be correlated with metabolic-inhibiting antibody. Lymphocytes taken from convalescent rats enhanced the clearance rates of recipient rats. Mouse convalescent lymphocytes were without effect. The results indicated that mice are less able to control long-term infection by M. arthritidis than are rats.
机译：在静脉内注射生物体后的最初2小时内，从大鼠和小鼠的外周循环中迅速清除了强毒的“支原体”菌株158 P10。在这段时间之后，典型的是，在48到72小时内，活生物体的数量保持了明显的恒定。无法清除剩余的支原体不是由于网状内皮内皮阻滞，而是似乎表明存在一定数量的对清除机制有抵抗力的细胞。大鼠血液通常在第6天没有支原体，而小鼠血液在第14天是无菌的。在这些时间之后偶尔发生暂时性支原体血症。无毒的 M。从非致关节炎的大鼠中更快地清除了关节炎菌株H606。使用 M在小鼠中获得了不同但特征性的清除曲线。 Hominis，M。bovirhinis 和 M。肺炎。主动免疫程序可增强对毒性M的清除。大鼠关节炎。这些程序在小鼠中不太成功。使用恢复期血清对正常大鼠和小鼠进行被动免疫的结果表明，存在血清因子，该因子大大增强了从大鼠的清除率，但对小鼠的影响很小。该血清因子不能与代谢抑制抗体相关。从恢复期大鼠中提取的淋巴细胞可提高受体大鼠的清除率。小鼠恢复期的淋巴细胞没有作用。结果表明，小鼠无法控制 M的长期感染。关节炎比老鼠更重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号