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首页> 外文期刊>Infection and immunity >Ultrastructure of Mutants of Streptococcus mutans with Reference to Agglutination, Adhesion, and Extracellular Polysaccharide
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Ultrastructure of Mutants of Streptococcus mutans with Reference to Agglutination, Adhesion, and Extracellular Polysaccharide

机译：变形链球菌突变体的超微结构与凝集，粘附和细胞外多糖有关。

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摘要

An electron microscopic study of S. mutans 6715-13 wild type and representatives of three distinct classes of glucan synthesis-defective mutants (which fail to form adherent microbial plaques but agglutinate normally in the presence of exogenous glucans) disclosed the presence of two sucrose-dependent, glucanase-sensitive, extracellular components. In the wild type, these extracellular glucans had predominantly fibrillar (with some globular) morphologies. However, in the mutant strains, there was a consistent reduction in or loss of the fibrillar components and dramatic increases in globular forms. A cell surface-associated fuzzy coat was consistently seen, and it was neither sucrose-dependent nor glucanase-sensitive. The data indicated that in vitro and in vivo adhesion and virulence at smooth tooth surfaces (all these properties dramatically reduced in the mutants) were causally and functionally related to the extracellular, fibrillar, glucan component, whereas in vitro glucan-mediated agglutination may be related to the cell-associated surface fuzzy coat.
机译： S的电子显微镜研究。突变体 6715-13野生型和三种不同类别的葡聚糖合成缺陷型突变体（不能形成粘附的微生物斑块，但在存在外源葡聚糖的情况下通常会凝集）的代表揭示了存在两种依赖于蔗糖的葡聚糖酶敏感的细胞外成分。在野生型中，这些细胞外葡聚糖主要具有纤维状（具有一些球状）形态。但是，在突变菌株中，原纤维成分持续减少或丢失，球状形式显着增加。始终可见细胞表面相关的模糊涂层，它既不依赖蔗糖也不敏感于葡聚糖酶。数据表明，在光滑牙齿表面的体外和体内黏附力和毒力（突变体中所有这些特性均显着降低）与细胞外，纤维状，葡聚糖成分有因果关系和功能相关，而体外葡聚糖介导的凝集作用可能是相关的单元相关的表面模糊涂层。

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