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首页> 外文期刊>Infection and immunity >Effect of alveolar macrophages on Toxoplasma gondii.
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Effect of alveolar macrophages on Toxoplasma gondii.

机译：肺泡巨噬细胞对弓形虫的影响。

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As pulmonary involvement can occur in disseminated toxoplasmosis in immunosuppressed patients, studies were initiated to define local mechanisms of resistance of the lung to Toxoplasma gondii. Alveolar macrophages were obtained from normal mice and mice chronically infected with T. gondii by bronchopulmonary lavage and cultured in vitro. Although normal alveolar macrophages were difficult to infect with Toxoplasma, they supported intracellular multiplication of this organism. When exposed to Toxoplasma that had been pretreated with heat-inactivated serum containing specific antibody, the number of intracellular organisms increased remarkably, and the macrophages destroyed the coated parasites. After development of chronic infections with Toxoplasma, there was a transient period during which a striking increase in numbers of alveolar macrophages was observed in lavage specimens. These macrophages differed from those of normal alveolar macrophages. There was a greater percentage of large cells, a greater tendency to spread on glass, and an increased number of intracellular Toxoplasma, and the cells were activated to kill or inhibit multiplication of the parasite. During the period when activated macrophages were demonstrable in bronchopulmonary washings, histological changes in the lungs revealed a marked mononuclear cell infiltrate. These studies support a role for the activated alveolar macrophage as an effector in resistance of the lung to infection with Toxoplasma.
机译：由于在免疫抑制患者中弥漫性弓形虫病可发生肺部受累，因此开始进行研究以定义肺部对弓形虫的耐药性局部机制。从正常小鼠和通过支气管肺灌洗法长期感染弓形虫的小鼠中获得肺泡巨噬细胞，并进行体外培养。尽管正常的肺泡巨噬细胞很难被弓形虫感染，但是它们支持这种生物的细胞内增殖。当暴露于用含有特定抗体的热灭活血清预处理的弓形虫中时，细胞内生物的数量显着增加，巨噬细胞破坏了被包被的寄生虫。在弓形虫慢性感染发生后，有一个过渡时期，在此期间，灌洗标本中的肺泡巨噬细胞数量显着增加。这些巨噬细胞不同于正常的肺泡巨噬细胞。大细胞百分比更高，在玻璃上扩散的趋势更大，细胞内弓形虫数量增加，细胞被激活以杀死或抑制寄生虫的繁殖。在支气管肺冲洗液中可证实活化的巨噬细胞期间，肺部的组织学变化显示明显的单核细胞浸润。这些研究支持了活化的肺泡巨噬细胞在肺部对弓形虫感染的抵抗力中的作用。

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