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首页> 外文期刊>Infection and immunity >Lymphocyte-mediated cytotoxicity in humans during revaccination with vaccinia virus.
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Lymphocyte-mediated cytotoxicity in humans during revaccination with vaccinia virus.

机译：牛痘病毒再接种过程中对人体的淋巴细胞介导的细胞毒性作用。

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Fifteen healthy human volunteers were revaccinated with vaccinia virus. Blood samples (4 to 7) were obtained during the 3 weeks after revaccination. Peripheral blood lymphocytes were washed extensively and tested for cytotoxicity against vaccinia-infected autologous and/or homologous skin fibroblasts. Without addition of antibodies, peak levels of killing were observed on days 7 to 9. The killing did not depend on common HLA markers. On days with peak activity, extensively washed lymphocytes showed higher levels of killing than normally washed lymphocytes. By cell separation experiments, the cell most active in killing proved to be a nonadherent, non-phagocytizing lymphocyte with Fc receptors. Serum antibodies tested in two sensitive serological assays peaked on days 14 to 17. The question of whether the killing observed is dependent on or independent of antibodies is not clarified in the present study.
机译：15名健康的人类志愿者接种了牛痘病毒。疫苗接种后3周内获得了血液样本（4至7个）。广泛洗涤外周血淋巴细胞，并测试其对牛痘感染的自体和/或同源皮肤成纤维细胞的细胞毒性。在不添加抗体的情况下，在第7至9天观察到了最高的杀灭水平。杀灭不依赖于常见的HLA标记。在活性达到峰值的几天，广泛洗涤的淋巴细胞比正常洗涤的淋巴细胞显示出更高的杀伤水平。通过细胞分离实验，证明杀伤活性最高的细胞是具有Fc受体的非粘附性，非吞噬性淋巴细胞。在两次敏感的血清学检测中测试的血清抗体在第14至17天达到峰值。在本研究中，尚不清楚所观察到的杀伤是依赖于抗体还是独立于抗体的问题。

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