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首页> 外文期刊>Infection and immunity >In Vivo Release of Previously Cleared Interferon by Cycloheximide
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In Vivo Release of Previously Cleared Interferon by Cycloheximide

机译：Cycloheximide体内释放先前清除的干扰素

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The release of previously cleared interferon by cycloheximide was studied in the mouse. When cycloheximide was administered after either endogenous interferon stimulation or administration of exogenous interferon, the clearance of interferon from the blood stream was interrupted and a sharp rise in interferon titer occurred approximately 6 hr after cycloheximide administration followed by a rapid decline to low levels. This effect was observed with either interferon stimulated endogenously (by polyriboinosinic·polyribocytidylic acid), or homologous (mouse) or heterologous (rabbit) interferon administered exogenously. Serum protein concentrations also exhibited this rise and fall phenomenon after cycloheximide administration although the magnitude of the change in protein concentrations was less pronounced than that observed with interferon. Hematocrits, although elevated in mice receiving cycloheximide, did not exhibit this rise and fall phenomenon. Hence, cycloheximide administration leads to the release into the circulation of previously cleared interferon as well as other proteins.
机译：在小鼠中研究了环己酰亚胺释放先前清除的干扰素。在内源性干扰素刺激或外源性干扰素给药后给予环己酰亚胺时，干扰素从血流中的清除被中断，并且在环己酰亚胺给药后约6小时，干扰素滴度急剧上升，随后迅速下降至低水平。内源性刺激（通过聚核糖核酸·聚核糖核酸）刺激干扰素，或外源性施用同种（小鼠）或异源（兔子）干扰素，均可观察到这种效果。服用环己酰亚胺后，血清蛋白质浓度也表现出这种上升和下降现象，尽管蛋白质浓度变化的幅度没有干扰素观察到的明显。尽管在接受环己酰亚胺的小鼠中血细胞比容升高，但并未表现出这种上升和下降现象。因此，环己酰亚胺的给药导致先前清除的干扰素以及其他蛋白质释放到循环中。

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