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首页> 外文期刊>Infection and immunity >Effect of thymectomy and antilymphocyte serum on Mycobacterium leprae infection in mice.
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Effect of thymectomy and antilymphocyte serum on Mycobacterium leprae infection in mice.

机译：胸腺切除术和抗淋巴细胞血清对小鼠麻风分枝杆菌感染的影响。

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BALB/c mice thymectomized at 3 to 5 days of age were studied to determine if this procedure would result in enhanced susceptibility to infection with Mycobacterium leprae and, if so, whether or not administration of antilymphocyte serum would further increase this susceptibility. The plateau for growth in the footpads of intact mice occurred 4 months after inoculation, whereas in the thymectomized and thymetocomized plus antilymphocyte serum-treated groups the plateau occurred between months 11 and 12 after inoculation. Thymectomy resulted in at least a 10-fold increase in the number of M. leprae found in the footpads. Antilymphocyte serum did not appear to further enhance the M. leprae infection in the thymectomized mice. Although growth of M. leprae in the testes of both intact and thymectomized mice was erratic, the number of organisms reached a higher ceiling in the thymectomized groups. M. leprae harvested from all groups was passaged into intact mice at various intervals after inoculation to test for viability. Viable M. leprae were found at all intervals tested including 22 months after infection in the intact mice, suggesting that a chronic infection occurred that probably lasted during the entire life of the animals.
机译：研究了在3至5天被胸腺切除的BALB / c小鼠，以确定该程序是否会导致麻风分枝杆菌感染的易感性增加;如果是，则施用抗淋巴细胞血清是否会进一步增加这种易感性。完整小鼠的脚垫生长的平台期在接种后4个月发生，而在经胸腺切除和胸腺切除加上抗淋巴细胞血清治疗的组中，平台期发生在接种后11到12个月之间。胸腺切除术导致在脚垫中发现的麻风杆菌数量至少增加了10倍。在胸腺切除的小鼠中，抗淋巴细胞血清似乎没有进一步增强麻风分枝杆菌的感染。尽管在完整小鼠和经胸腺切除的小鼠的睾丸中麻风杆菌的生长均不稳定，但在经胸腺切除的小鼠中，细菌的数量达到了上限。接种后，从各个组收获的麻疯分枝杆菌以不同的间隔传给完整的小鼠，以测试其存活力。在所有测试的时间间隔（包括感染后22个月）中，在完整小鼠中均发现了活麻风杆菌，这表明发生了可能在动物的整个生命中持续的慢性感染。

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