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首页> 外文期刊>Infection and immunity >Evaluation of type-specific and non-type-specific pseudomonas vaccine for treatment of pseudomonas sepsis during granulocytopenia.
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Evaluation of type-specific and non-type-specific pseudomonas vaccine for treatment of pseudomonas sepsis during granulocytopenia.

机译：评价特定类型和非特定类型假单胞菌疫苗治疗粒细胞减少症中的假单胞菌败血症。

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摘要

The protective role of serotype-specific and non-type-specific active immunity against Pseudomonas aeruginosa infection was assessed in granulocytopenic dogs. Dogs were preimmunized with either specific serotype 6 vaccine (SI) or nonspecific serotype 3 vaccine (NSI) and challenged intravenously with 10(7) viable serotype 6 P. aeruginosa during granulocytopenia. Control dogs (C) having insignificant anti-pseudomonas antibody levels were also tested. Results showed: (i) significant increase in survival of SI dogs (P less than 0.05) compared to C and NSI dogs, with no significant difference between C and NSI animals; (ii) lower febrile responses in SI dogs; and (iii) markedly reduced bacteremia in SI dogs compared to C and NSI animals. SI dog sera from survivor animals did not kill the infecting pseudomonas strain in vitro. The study demonstrated that type-specific immunity to P. aeruginosa induced by active immunization is effective in protection against pseudomonas during granulocytopenia and that non-type-specific immunity offers no cross-reactive protection. The findings suggest that the reticuloendothelial system in conjunction with specific immunity constitute an important defense against pseudomonas infections.
机译：在粒细胞减少症犬中评估了血清型特异性和非类型特异性主动免疫对铜绿假单胞菌感染的保护作用。用特异血清型6疫苗（SI）或非特异血清型3疫苗（NSI）对狗进行预免疫，并在粒细胞减少症期间用10（7）活泼血清型6铜绿假单胞菌静脉内攻击。还测试了具有微不足道的抗假单胞菌抗体水平的对照犬（C）。结果显示：（i）与C和NSI狗相比，SI狗的存活率显着提高（P小于0.05），C和NSI动物之间无显着差异; （ii）SI犬的发热反应降低; （iii）与C和NSI动物相比，SI狗的菌血症明显减少。来自存活动物的SI狗血清在体外没有杀死感染的假单胞菌菌株。该研究表明，主动免疫诱导的针对铜绿假单胞菌的类型特异性免疫可有效预防粒细胞减少症中的假单胞菌，而非类型特异性免疫则无法提供交叉反应性保护。这些发现表明，网状内皮系统结合特异性免疫力构成了针对假单胞菌感染的重要防御手段。

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