Trypanosoma rhodesiense infection in B-cell-deficient mice.

G H Campbell; K M Esser; F I Weinbaum

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Trypanosoma rhodesiense infection in B-cell-deficient mice.

机译：B细胞缺陷型小鼠的罗氏锥虫感染。

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B-cell-deficient C57B1/6J mice (suppressed from birth with goat anti-mu) and controls (treated from birth with normal goat serum) were infected with Trypanosoma rhodesiense. There was a significant (P less than 0.01) decrease in duration of survival of the mu-suppressed mice compared with that of controls. Whereas both mu-suppressed and control mice had an initial rise in parasitemia of similar magnitude, only the control mice exhibited a subsequent period during which the parasitemia fell to undetectable levels. In control mice, immunization with irradiated organisms prevented the development of detectable parasitemia after challenge with viable trypanosomes. However, immunization did not alter the course of infection in B-cell-deficient mice. These results indicate that immunity to T. rhodesiense infection in mice is dependent on B-cell immunocompetence.

机译：B细胞缺陷型C57B1 / 6J小鼠（出生时被山羊抗mu抑制）和对照组（出生时用正常山羊血清治疗）被罗氏锥虫感染。与对照组相比，被mu抑制的小鼠的生存期显着减少（P小于0.01）。尽管mu抑制小鼠和对照组小鼠的寄生虫病初期都有相似程度的上升，但只有对照组小鼠表现出随后的一段时间，在此期间寄生虫病降至不可检测的水平。在对照小鼠中，用活的锥虫攻击后，用辐照过的生物体进行免疫可以防止可检测到的寄生虫病的发生。但是，免疫接种并未改变B细胞缺陷小鼠的感染过程。这些结果表明，小鼠对罗德氏支原体感染的免疫力取决于B细胞的免疫能力。

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《Infection and immunity》 |1977年第2期|共5页
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G H Campbell; K M Esser; F I Weinbaum;
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中图分类医学免疫学;
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1. Trypanosoma musculi infection in B-cell-deficient mice. [J] . F D Vargas, P Viens, P A Kongshavn Infection and immunity . 1984,第1期

机译：B细胞缺陷小鼠中的锥虫锥虫感染。
2. Trypanosoma rhodesiense infection in congenitally athymic (nude) mice. [J] . G H Campbell, K M Esser, S M Phillips Infection and immunity . 1978,第3期

机译：先天性无胸腺（裸）小鼠的罗得氏锥虫感染。
3. Plasma nitrate and interferon-gamma in Trypanosoma brucei rhodesiense infections: evidence that nitric oxide production is induced during both early blood-stage and late meningoencephalitic-stage infections. [J] . MacLean L, Odiit M, Okitoi D, Transactions of the Royal Society of Tropical Medicine and Hygiene . 1999,第2期

机译：罗氏锥虫感染中的血浆硝酸盐和干扰素-γ：证据表明一氧化氮的产生是在早期血液阶段和晚期脑膜脑病阶段感染中引起的。
4. The influence of when therapy is initiated upon the efficacy of cidofovir in topical treatment of cutaneous hsv-1 infection in hairless mice. [C] . Mohsen I. afouna, Samir C. Mehta, Abdel-Halim Ghanem, International symposium on controlled release of bioactive materials . 1998

机译：在无毛小鼠中肝脏皮肤HSV-1感染的局部治疗术后疗法的影响。
5. Immunostimulatory DNA and the innate immune response to Trypanosoma brucei rhodesiense. [D] . Harris, Tajie Heartsong. 2007

机译：免疫刺激性DNA和对布氏锥虫的先天免疫反应。
6. Trypanosoma rhodesiense infection in B-cell-deficient mice. [O] . G H Campbell, K M Esser, F I Weinbaum 1977

机译：B细胞缺陷型小鼠的罗氏锥虫感染。
7. TNF-α mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection [O] . Naessens, J, Kitani, H, Nakamura, Y, 2005

机译：TNF-α介导鼠类布鲁氏锥虫感染中贫血的发生，但不介导与小鼠锥虫锥虫感染有关的贫血
8. 'Trypanosoma Rhodesiense' Infection in the Congenitally Athymic (Nude) Mice. [R] . Campbell, G. H., Esser, K. M., Phillips, S. M. 1977

机译：先天性无胸腺（裸）小鼠的'Trypanosoma Rhodesiense'感染。

Trypanosoma rhodesiense infection in B-cell-deficient mice.

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