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首页> 外文期刊>Infection and immunity >Inability of spleen cells from chancre-immune rabbits to confer immunity to challenge with Treponema pallidum.
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Inability of spleen cells from chancre-immune rabbits to confer immunity to challenge with Treponema pallidum.

机译：不能进行下腹部免疫的家兔的脾细胞不能赋予抵抗梅毒螺旋体的免疫力。

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Although several lines of evidence suggest that cellular immune mechanisms play a role in controlling infection due to Treponema pallidum, recent studies have shown that induction of acquired cellular resistance by antigenically unrelated organisms fails to protect rabbits against syphilitic infection, thereby casting doubt on this hypothesis. In the present paper we describe attempts to transfer immunity to syphilis by using spleen cells from chancre-immune rabbits. Intravenous infusion of 2 X 10(8) spleen lymphocytes was capable of transferring acquired cellular resistance to Listeria and delayed hypersensitivity to tuberculin. However, in eight separate experiments using outbred or inbred rabbits, 2 X 10(8) spleen cells from syphilis-immune animals failed to confer resistance to T. pallidum whether by intravenous or intradermal challenge. Mixing immune lymphocytes with treponemes immediately before intradermal inoculation also failed to confer resistance. Despite the fact that syphilitic infection stimulates cellular immune mechanisms and induces acquired cellular resistance to antigenically unrelated organisms, cellular immunity may not play an important role in immunity to syphilis.
机译：尽管有几条证据表明细胞免疫机制在控制由梅毒螺旋体引起的感染中起作用，但最近的研究表明，与抗原无关的生物体诱导获得性细胞抗性不能保护兔子免受梅毒感染，因此对该假说产生怀疑。在本文中，我们描述了通过使用经胰脏免疫的家兔的脾细胞将免疫力转移至梅毒的尝试。静脉输注2 X 10（8）脾淋巴细胞能够将获得的细胞抗性转移至李斯特菌，并延迟对结核菌素的超敏反应。但是，在八个使用近交或近交兔子的单独实验中，无论是通过静脉内还是皮内刺激，来自梅毒免疫动物的2 X 10（8）脾细胞均未能赋予对苍白螺旋体的抗性。皮内接种前立即将免疫淋巴细胞与色氨酸混合，也无法产生耐药性。尽管梅毒感染会刺激细胞免疫机制并诱导获得的对非抗原相关生物的细胞抗性，但细胞免疫可能不会在梅毒免疫中起重要作用。

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