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首页> 外文期刊>Infection and immunity >Inability of immune cells treated with anti-thymocyte serum to confer on hamsters resistance to cutaneous infection with Treponema pertenue.
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Inability of immune cells treated with anti-thymocyte serum to confer on hamsters resistance to cutaneous infection with Treponema pertenue.

机译：用抗胸腺细胞血清处理的免疫细胞无法赋予兔子患者对皮肤感染的兔抗皮肤感染。

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The mechanism by which hamsters acquire resistance to yaws or frambesia is poorly understood. This investigation has shown that immune lymphoid cells (spleen and lymph node) could confer on hamsters resistance to infection with Treponema pertenue. Treatment of these immune cells with a specific antithymocyte serum (ATS) inhibited the transfer of resistance. Twenty-one days after infection, recipients of immune cells treated with ATS had cutaneous lesions, in contrast to recipients of immune cells treated with normal rabbit serum. Treatment of immune cells with ATS, however, did not completely abolish resistance to treponemal infection. The weight and number of treponemes in the lymph nodes of recipients were significantly lower than those infused with normal cells treated with ATS or normal rabbit serum. The specificity of the ATS was demonstrated by its failure to inhibit functional antibody-producing cells and its high cytotoxic activity for thymocytes. These results present direct evidence that ATS-sensitive cells are involved in resistance to frambesial infection.
机译：仓鼠获得抗锯齿或弗拉布斯潜力的机制很差。该研究表明，免疫淋巴细胞（脾脏和淋巴结）可以赋予兔子患者对患有Treponema产卵的感染的抵抗力。用特异性抗细胞血清（ATS）处理这些免疫细胞抑制抗性的转移。感染后二十一天，用ATS治疗的免疫细胞的受体具有皮肤病因果，与用正常兔血清处理的免疫细胞受体相反。然而，用ATS治疗免疫细胞并未完全消化对葡萄糖感染的抗性。受体的淋巴结中的粒子的重量和数量显着低于用ATS或普通兔血清处理的正常细胞的那些。通过其未能抑制功能性抗体产生细胞及其对胸腺细胞的高细胞毒性活性来证明ATS的特异性。这些结果目前的直接证据表明ATS敏感细胞涉及抗扰乱感染的抗性。

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