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Lecithin Changes in Murine Mycoplasma pulmonis Respiratory Infection

机译：小鼠肺部支原体呼吸道感染中卵磷脂的变化

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We examined the lipid content of bronchoalveolar (BA) washes from both mice and rats infected with Mycoplasma pulmonis, an etiological agent of murine pneumonia. During a 30-day period after intranasal inoculation, the total lipid content from infected and control rats (in milligrams per animal) remained relatively equal and unchanged. The saturated, unsaturated, and total lecithin contents in infected rats (in milligrams per animal) all increased. The maximum lecithin values were detected at 7 to 10 days after infection; later, the levels fell to control values. There was essentially no change in any lecithin value from uninfected animals. Although in BA washes from infected animals the mass of disaturated lecithins increased, the percentage of this fraction in the total lecithin pool decreased. The fatty acids of the lecithins from BA washes of infected mice had significantly less palmitic and significantly more oleic and linoleic acids than the lecithins isolated from the BA washes of control animals. Both the relative decrease in the mass of disaturated lecithins in the BA washes and the increase in the percentage of esterified unsaturated fatty acids in the lecithins may be directly related to the reduced lung function reported to occur during the course of murine M. pulmonis pneumonia.
机译：我们检查了感染鼠源性肺炎支原体肺炎支原体的小鼠和大鼠支气管肺泡（BA）洗涤液的脂质含量。鼻内接种后的30天期间，感染和对照大鼠的总脂质含量（每只动物毫克）保持相对相等且不变。受感染大鼠的卵磷脂中饱和，不饱和和总卵磷脂含量（每只动物毫克）均增加。在感染后7至10天检测到最大卵磷脂值。后来，水平下降到控制值。未感染动物的卵磷脂值基本没有变化。尽管在感染动物的BA洗涤中，饱和卵磷脂的质量增加了，但在总卵磷脂库中该部分的百分比却降低了。与从对照动物的BA洗涤物中分离的卵磷脂相比，来自感染小鼠的BA洗涤物中的卵磷脂的脂肪酸具有显着更少的棕榈酸，以及明显更多的油酸和亚油酸。 BA洗涤中饱和卵磷脂质量的相对下降和卵磷脂中酯化不饱和脂肪酸百分比的增加都可能与鼠M过程中发生的肺功能下降直接相关。肺炎。

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