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首页> 外文期刊>Infection and immunity >Increased severity of urinary tract infection and bacteremia in mice with urinary bladder injury induced by cyclophosphamide.
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Increased severity of urinary tract infection and bacteremia in mice with urinary bladder injury induced by cyclophosphamide.

机译：环磷酰胺诱发的膀胱损伤小鼠的尿路感染和菌血症严重程度增加。

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The effect of cyclophosphamide on urinary tract infection was studied, using Pseudomonas aeruginosa in a murine model. Urinary tract infections were produced by injecting P. aeruginosa through a urethral catheter into the bladders of mice. The number of P. aeruginosa organisms in the bladder tissue and kidneys, histopathology, peripheral leukocyte count, and antibody response to P. aeruginosa was measured. The local effect of cyclophosphamide on the bladder was determined by measuring the bladder tissue water and examining the histopathology. Cyclophosphamide increased the susceptibility of mice to P. aeruginosa urinary tract infection, resulting in marked cystitis and an increase in renal infection, bacteremia, and mortality. These changes correlated with the toxic effect of cyclophosphamide on the wall of the bladder rather than with peripheral leukopenia or failure of antibody response.
机译：在鼠模型中使用铜绿假单胞菌研究了环磷酰胺对尿路感染的影响。尿道感染是通过经尿道导管将铜绿假单胞菌注射到小鼠膀胱中而产生的。测量了膀胱组织和肾脏中的铜绿假单胞菌生物体数量，组织病理学，外周血白细胞计数以及对铜绿假单胞菌的抗体反应。通过测量膀胱组织水并检查组织病理学来确定环磷酰胺对膀胱的局部作用。环磷酰胺增加了小鼠对铜绿假单胞菌尿路感染的敏感性，导致明显的膀胱炎，并增加了肾脏感染，菌血症和死亡率。这些变化与环磷酰胺对膀胱壁的毒性作用有关，而不是与外周白细胞减少或抗体应答失败有关。

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